One of the effective approaches to develop new anticancer drugs is to prepare polymeranticancer drug conjugates. The polymer-anticancer drug conjugates include polymerprotein conjugates, polymer-drug conjugates and supramolecular drug-delivery systems. In 1975, the concept of a polymer-drug conjugate was first proposed by Ringsdorf (Ringsdorf, 1975). In his model, a bioactive anticancer agent w...

BACKGROUND The hydrogel based system is found to be rarely reported for the delivery of hydrophobic drug due to the incompatibility of hydrophilicity of the polymer network and the hydrophobicity of drug. This problem can be solved by preparing semi-interpenetrating network of cross-linked polymer for tuning the hydrophilicity so as to entrap the hydrophobic drugs. The current study is to devel...

Objective: The objective of the present study is a determination of optimal ratios of polyethylene glycol:sulfanilamide at which formation of solid dispersion is observed. Also study the effect of the polymer on the limiting solubility of sulfanilamide in water. Methods: Using low-temperature differential scanning calorimetry (DSC), it was made possible to obtain solid dispersions of sulfanilam...

Poor drug encapsulation efficiency and rapid release of the encapsulated drug limit the use of nanoparticles in biomedical applications involving water-soluble drugs. We have developed a novel polymer-surfactant nanoparticle formulation, using the anionic surfactant Aerosol OT (AOT) and polysaccharide polymer alginate, for sustained release of water-soluble drugs. Particle size of nanoparticles...