background: chromosomal disorders are the most common cause of first trimester spontaneous abortion. among the human chromosomes, chromosome no.9 was the most common structural chromosomal variant and it is not thought to be of any functional importance, which often considers as a normal variation in structural polymorphisms, nevertheless there are some studies which claim that there is an asso...

0 answer the new questions being raised about polygenes and polygenic systems, for example, on the nature of the interactions between specific loci or on the presence of a specific allele in independent selections, requires a special methodology of polygenic analysis. The heart of this methodology is the ability to make controlled substitutions of one gene for its allele in several defined comb...

BACKGROUND Pharmacogenetic-based dosing support tools have been developed to personalize antidepressant-prescribing practice. However, the clinical validity of these tools has not been adequately tested, particularly for specific antidepressants. OBJECTIVE To examine the concordance between the actual dose and a polygene pharmacogenetic predicted dose of desvenlafaxine needed to achieve sympt...

in this study the nature of chromosomal proteins, his tones and nonhistone in resident alveolar macrophages was investigated in comparison to peritoneal neutrophils and calf thymus proteins. cells were obtained by lavaging the lung and after purity determination they were subjected to fractional extraction procedures. proteins were then analysed on sds polyacrylamide gels and densitometric scan...

BACKGROUND There are few reports describing chromosomal abnormalities in transsexuals. In rare cases, transsexualism and sexual chromosomal multiplicity coexist. Six cases of male-to-female transsexuals with 47,XYY chromosomal pattern have been previously reported. We have not encountered any female transsexual cases with 47,XXX karyotype in the literature. METHODS A 21-year-old female patien...