نتایج جستجو برای: pni

تعداد نتایج: 588  

2015
Christina Springstead Scanlon Rajat Banerjee Ronald C Inglehart Min Liu Nickole Russo Amirtha Hariharan Elizabeth A van Tubergen Sara L Corson Irfan A Asangani Charlotte M Mistretta Arul M Chinnaiyan Nisha J D’Silva

Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately, there is no targeted treatment for PNI since the molecular mechanisms are largely unknown. PNI is an active process, suggesting that cancer cells communicate with nerves. However, nerve-tumour crosstalk is understudied due to the lack of in vivo models to investigate the mechanisms. Here we developed ...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Yu-Mei Jiang Guang Li Bao-Cun Sun Xiu-Lan Zhao Zhong-Kai Zhou

BACKGROUND Recent reports have shown that C-X-C chemokine receptor 4 (CXCR4) plays an important role in metastasis. Despite a clear understanding of the protein's structure and properties, its functional role remains elusive. We conducted the present study to evaluate the expressions of CXCR4 in pancreatic cancer, and to investigate its relationship with clinicopathological parameters, especial...

2016
Chenyue Zhang Haiyong Wang Zhouyu Ning Litao Xu Liping Zhuang Peng Wang Zhiqiang Meng

OBJECTIVE The significance of the prognostic nutritional index (PNI) has been widely reported and confirmed in many types of cancers. However, few studies are available indicating its prognostic power in patients with intrahepatic cholangiocarcinoma (ICC). Thus, we investigated its relationship with overall survival (OS) to evaluate its role in predicting survival in patients with ICC. PATIEN...

Journal: :Cancer research 2004
Gustavo E Ayala Hong Dai Michael Ittmann Rile Li Michael Powell Anna Frolov Thomas M Wheeler Timothy C Thompson David Rowley

Perineural invasion (PNI) is the major mechanism of prostate cancer spread outside the prostate. Apoptotic and proliferation indices were determined in PNI cells using the PNI in vitro model and human PNI in tissue microarrays. RNA was extracted from the PNI model and controls and evaluated by cDNA microarray analysis. Differential expression of candidate genes was confirmed by real-time quanti...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2015
Fahriye Tugba Kos Cemil Hocazade Mehmet Kos Dogan Uncu Esra Karakas Mutlu Dogan Hikmet Gulsen Uncu Nuriye Ozdemir Nurullah Zengin

BACKGROUND Systemic inflammatory response was shown to play an important role in development and progression of many cancer types and different inflammation-based indices were used for determining prognosis. We aimed to investigate the prognostic effects of neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) in patients with non-small cell lung cancer (NSCLC). MATERIAL...

Journal: :Head & neck 2016
Andrés M Bur Alexander Lin Gregory S Weinstein

Perineural invasion (PNI) is widely regarded as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Treatment guidelines recommend adjuvant radiotherapy (RT) for patients with adverse pathologic features, including PNI. The purpose of this study was to systematically review the literature to determine if patients with PNI as their only indication for adjuvant therapy ...

2016
Takahiro Masuda Yui Ozono Satsuki Mikuriya Yuta Kohro Hidetoshi Tozaki-Saitoh Ken Iwatsuki Hisayuki Uneyama Reiko Ichikawa Michael W Salter Makoto Tsuda Kazuhide Inoue

Activation of purinergic receptors in the spinal cord by extracellular ATP is essential for neuropathic hypersensitivity after peripheral nerve injury (PNI). However, the cell type responsible for releasing ATP within the spinal cord after PNI is unknown. Here we show that PNI increases expression of vesicular nucleotide transporter (VNUT) in the spinal cord. Extracellular ATP content ([ATP]e) ...

2015
Alma C. Berlingeri-Ramos Claire J. Detweiler Richard F. Wagner Brent C. Kelly

Background. Perineural invasion (PNI) is an adverse prognostic histologic finding and increases the risk of local recurrence and metastasis. Objective. We aimed to determine if dual immunohistochemical (IHC) staining with S-100 and AE1/3 would increase the detection of PNI on nonmelanoma skin cancers (NMSCs). Methods. We collected 45 specimens of NMSCs in which there was clinical suspicion for ...

Journal: :Cancer research 2017
Richard L Bakst Huizhong Xiong Chun-Hao Chen Sylvie Deborde Anna Lyubchik Yi Zhou Shizhi He William McNamara Sei-Young Lee Oakley C Olson Ingrid M Leiner Andrea R Marcadis James W Keith Hikmat A Al-Ahmadie Nora Katabi Ziv Gil Efsevia Vakiani Johanna A Joyce Eric Pamer Richard J Wong

Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells to enable PNI, but the contributing conditions within the tumor microenvironment are not well understood. Here, we show that CCR2-expressing inflammatory monocytes (IM) are preferentially recruited to sites of PNI, where they differentiate...

Journal: :Oncology reports 2014
Zhiyuan Shen Tianyi Li Da Chen Sen Jia Xiangming Yang Liang Liang Juan Chai Xiaobing Cheng Xinjie Yang Moyi Sun

Salivary adenoid cystic carcinoma (SACC) has a unique tendency for perineural invasion (PNI), which results in tumor recurrence and poor prognosis. Recent studies have shown that the chemokine CCL5 and its receptor CCR5 play important roles in tumor invasion and metastasis. However, the role of the CCL5/CCR5 axis in the PNI of SACC has not been studied to date. In the present study, we evaluate...

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