BACKGROUND Plumbagin is the major active constituent in several plants including Plumbago indica Linn. (root). This compound has been shown to exhibit a wide spectrum of biological and pharmacological activities. The present study aimed to evaluate the in vitro and in vivo antimalarial activity of plumbagin including its acute and subacute toxicity in mice. METHODS In vitro antimalarial activ...

For centuries, plants have been used to treat several diseases worldwide including wound healing, and are still playing a major role in healthcare systems in many developing countries. Wound is defined as the disruption of the cellular and anatomic continuity of a tissue and may be produced by physical, chemical, thermal, microbial or immunological insult to the tissues. The process of wound he...

A disease of Plumbago Zeylanica L. caused by Phoma exigua is reported for the first time from India.

OBJECTIVES The current investigation was carried out to determine the cytotoxic and the antimicrobial activities of methanolic extracts of Plumbago zeylanica. METHODS The stems, leaves, and whole plants were air dried and extracted with methanol by using a Soxhlet extractor for 72 hours at 55 - 60°C. The antimicrobial activities were determined from the zones of inhibition, which were measure...

BACKGROUND Diabetes mellitus is a metabolic disorder of epidemic proportion, projected to become the major cause of morbidity and mortality in the world in future. Despite extensive research in understanding this disease at molecular level, and the discovery of new drugs, diabetes and its complications remain largely untreated. Many of the late diabetic complications are associated with the gly...

The administration of Plumbago zeylanica root (50% EtOH) extract to |intact rats at the dose of 150 mg/kg [body weight for 60 days caused arrest of spermatogenesis. The diameter of seminiferous tubules and Leydig cell nuclei were reduced. The production of spermatocytes (primary and secondary) and spermatids were significantly reduced (P£ 0.001; 83.57%, 89.69% and 69.47% respectively). The tota...

Methanolic extracts of Plumbago zeylanica (Root), Acorus calamus (Rhizome), Hemidesmus indicus (Stem) and Holarrhena antidysenterica (Bark), used in Ayurvedic medicines for number of ailments were evaluated for their antioxidant activity by ferric thiocyanate (FTC) assay and compared with thiobarbituric acid (TBA) method. The order of antioxidant potential according to FTC assay was found to be...

Herbal products derived from Hemidesmus indicus (L.) R. Br. ex Schult, Leucas aspera (Wild.), Plumbago zeylanica L., and Tridax procumbens (L.) R. Br. ex Schult. are widely used in traditional medicine. Though the extracts of these plants were found to be antimicrobial in nature and have the potential to be used in clinics, the mechanism of action of is not reported. The ethanolic extracts of H...

Ayurveda is time-tested science of treating disease with natural things like plant, animals and minerals. It remains one of the most ancient and yet living traditions practised widely in India, Sri Lanka and other countries and has a sound philosophical and experiential basis. Plumbago zeylanica is commonly known as white chitraka, belongs to family plumbaginaceae. It is distributed as a weed t...