lsd=20m SAXS and SANS study of PLGA nanospheres containing a Poloxamer shell C. Augsten1, A. Rübe1, M.A. Kiselev2, R. Gehrke3, J. Kohlbrecher4, K. Mäder1 1 University Halle-Wittenberg, Institute of Pharmaceutical Technology and Biopharmacy, 06120 Halle, Germany 2 Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, 141980 Dubna, Russia 3 HASYLAB (DESY), 22603 Hamburg, Germ...

A wide range of nanoparticles has been explored for the delivery of highly hydrophobic drugs, but very few publications provide comparative data of the performance of different nanoparticles. To address this need, this publication compares poly(lactic-co-glycolic acid) (PLGA) nanoparticles and nanospheres made from tyrosine-derived tri-block copolymers (termed TyroSpheres) for their respective ...

Nanoparticles have been widely used for nonviral gene delivery. Recently, cationic hybrid nanoparticles consisting of two different materials were suggested as a promising delivery vehicle. In this study, nanospheres with a poly(D,L-lactic-co-glycolic acid) (PLGA) core and cationic lipid shell were prepared, and the effect of cationic lipid concentrations on the properties of lipid polymer hybr...

The development of nonviral vectors for the efficient and safe delivery to cells has long been awaited to facilitate gene therapy. Recently, many nonviral vectors modified with cationic lipids, cationic polymers, etc. have been reported. However, those nonviral vectors with cationic materials require improved stability, longer duration of gene expression, and reduced cytotoxicity. We successful...

Using poly(lactide-co-glycolide) (PLGA) particles for drug encapsulation and delivery has recently gained considerable popularity for a number of reasons. An advantage in one sense, but a drawback of PLGA use in another, is that drug delivery systems made of this material can provide a wide range of dissolution profiles, due to their internal structure and properties related to particles' manuf...