نتایج جستجو برای: platinum iv complexes

تعداد نتایج: 330620  

Journal: :Inorganic chemistry 2007
Avery T Luedtke Karen I Goldberg

Five-coordinate platinum(IV) alkyl complexes bearing sterically non-demanding pyridylpyrrolide ligands, (LX)PtMe(3) [LX = 3,5-di-tert-butyl-2-(2-pyridyl)pyrrolide (3a) and 3,5-diphenyl-2-(2-pyridyl)pyrrolide (3b)] have been prepared. An X-ray structure of 3a establishes that it is a five-coordinate Pt(IV) complex with a square-pyramidal geometry. Thermolysis of 3a or 3b in C(6)D(6) with ethylen...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2003
Daniel Kushev Emilya Naydenova Julita Popova Liliana Maneva Konstantin Grancharov Nadejda Spassovska

Four new platinum(II) complexes of 3-aminocyclopentanespiro-5-hydantoin (acpsh) and 3-aminocycloheptanespiro-5-hydantoin (achpsh) were synthesized and characterized by elemental analysis, IR and 1NMR spectra. The spectral analyses indicated a cis-square planar structure of the complexes with ligands coordinated via the NH2 group. The complexes were evaluated for in vitro cytotoxicity in murine ...

Journal: :Dalton transactions 2012
Hristo P Varbanov Seied M Valiahdi Christian R Kowol Michael A Jakupec Markus Galanski Bernhard K Keppler

It is widely accepted that platinum(IV) complexes act as prodrugs and have to be activated by reduction to the respective platinum(II) analogs. Recently it could be shown that introduction of lipophilic carboxylato ligands in the axial position leads to diaminedichloridoplatinum(IV) compounds with exceptionally high cytotoxicity. With the aim of improving the antiproliferative properties of car...

Journal: :Biochimie 2009
Ana M Pizarro Peter J Sadler

DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis. New platinum drugs can be designed that have novel modes of interaction with DNA, such as the trinuclear platinum complex BBR3464. Also it is possible to design inert platinum(IV) pro-drugs which are non-toxic in the dark, but ...

Journal: :The Journal of Cell Biology 1985
A S Charonis E C Tsilibary P D Yurchenco H Furthmayr

A mixture of laminin and type IV collagen was analyzed by rotary shadowing using carbon/platinum and electron microscopy. Laminin was found to form distinct complexes with type IV collagen: one site of interaction is located 140 nm from the COOH-terminal, noncollagenous (NC1) domain and the other is located within the NH2-terminal region. The isolated NC1 fragment of type IV collagen does not a...

2014
Gerhard Hamilton

In attempts to develop an orally applicable platinum-based drug, platinum(IV) drugs which exhibit higher in vivo stability compared to the platinum(II) drug cisplatin were formulated. The first such chemotherapeutic agent, namely satraplatin, failed to receive approval. In the present work, we checked the initial cellular stress response of the chemosensitive NCI-H526 small cell lung cancer (SC...

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