frozen shoulder is a glenohumeral joint disorder that perturbs movement because of adhesion and the existence of fibrosis in the shoulder capsule. platelet-rich plasma can produce collagen and growth factors, which increases stem cells and consequently enhances the healing. to date, there is no evidence regarding the effectiveness of platelet-rich plasma in frozen shoulder. a 45-year-old man wi...

Platelet dense granule release assays are recommended for diagnosing platelet function disorders and are commonly performed by Lumi-Aggregometer (Chrono-Log, Havertown, PA) assays of adenosine triphosphate (ATP) release. We conducted a prospective cohort study of people tested for ATP release defects to assess bleeding symptoms. Reduced release, with 1 or more agonists, was more common among pa...

This paper described two methods for the detection ofserum antiplatelet tgC antibody (a platelet-factor-3 immuno-in jury technique and a Dextran-agglutination technique) in patients with idiopathic thrombocytopenic purpura, a bleeding disorder with a disputed etiology. Proofwas provided that the antiplateletfactor present in the serum of these individuals was an lgC imnaunoglobulin, providing e...

Patients who were in good health, with no history of any drug ingestion or recent travel, presented with spontaneous widespread bruising and ecchymosismainly on the extremities. No history of severe bleeding was noted. These patients on laboratory evaluation did not show any abnormalities in basic hemostatic screen with BT (Bleeding Time), CT (Clotting time), PT (Prothrombin Time), APTT (Activa...

A patient with features of a myeloproliferative disorder developed an acute multisystems illness and died. In-vitro platelet aggregation was imparied, but necropsy revealed widespread platelet-rich thromboemboli and multiple organ infarctions. It is suggested that platelets are damaged during disseminated intravascular platelet aggregation (DIPA) and that disaggregation of platelet thrombi and ...

UNLABELLED The involvement of brain serotonin systems in the pathophysiology of eating disorders has been repeatedly demonstrated in recent studies. Platelet MAO activity is an index of brain serotonin activity and lowered platelet MAO levels have been found in association with impulsive behaviors. In addition, some preliminary reports indicate that platelet MAO could be lowered in eating disor...

The objective of this study was to determine if platelet 5-HT transporter (5-HTT) sites vary as a function of aggression, and/or impulsiveness, and differ as a function of Intermittent Explosive Disorder (IED). Accordingly, the number of platelet 5-HTT sites was assessed in 100 personality disordered (PD) individuals with varying degrees of aggressiveness. The number of platelet 5-HTT sites was...

Platelet function studies were performed on two patients with the Chediak-Higashi syndrome, one of whom had a history of easy bruising unrelated to thrombocytopenia. Both patients had prolonged bleeding times, abnormal platelet aggregation, and a defect of platelet storage granules, manifested by reduced platelet ADP, an increased ATP/ADP ratio, increased adenine nucleotide specific radioactivi...

BACKGROUND The aim of the present study was to assess the efficacy of vincristine-laden platelet transfusion for patients with refractory thrombocytopenia. PATIENTS AND METHODS Twenty evaluable patients who received vincristine-laden platelets for refractory thrombocytopenia were included in this retrospective study. Vincristine (1 mg) was added to the platelets and incubated for one hour pri...