BACKGROUND Patients experiencing massive haemorrhage are at high risk of developing coagulopathy through loss, consumption, and dilution of coagulation factors and platelets. It has been reported that plasma fibrinogen concentrations may reach a critical low level relatively early during bleeding, calling for replacement fibrinogen therapy. Cryoprecipitate has been widely used in the past, but ...

In a series of important studies Murphy and his colleagues demonstrated that the preparation and storage of platelet-rich plasma and platelet concentrates at 22°C rather than 4°C improved their life span in vivo (Murphy and Gardner, 1969; Murphy, Sayar, and Gardner, 1970). The potential clinical relevance of this finding has been confirmed by Handin and Valeri (1971), and it is likely that this...

BACKGROUND Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair. EXPERIMENT AND FINDINGS We studied whether a platelet concentrate injection would improve Achilles tendon repair in an established rat model. The Achilles tendon was transected and a 3 mm segment removed. After 6 h, a platelet concentrate was injected per...

The use of biologic augmentation following microfracture for symptomatic cartilage defects the knee with osseous involvement shows encouraging results. Bone marrow aspirate concentrate provides growth factors to injury site, such as vascular endothelial factor, platelet-derived transforming factor-βa, and bone morphogenetic proteins in addition mesenchymal stem cells present concentrate. Cellul...

PURPOSE To describe the long-term clinical course in children with a traumatic macular hole after vitrectomy with platelet concentrate. DESIGN Interventional case series. METHODS Four pediatric patients with a mean age of 13.2 years (range, 10-15 years) underwent pars plana vitrectomy with platelet concentrate, internal limiting membrane peeling, and SF6 gas tamponade for stage 3 traumatic ...

Introduction:The use of autogenous concentrated blood products, particularly platelets, has become increasingly widespread as an effective clinical tool to accelerate wound healing. Upon activation, platelets release cytokines (i.e PDGF and TGFß1) and platelet membrane particles (PMP). Major obstacles to understanding the mechanisms of these clinical successes lie in the many different clinical...