the interaction of sulfur mustard with aminoacids and proteins has been investigated in this study. rats were injected with sublethal doses of sulfur mustard subcutaneously and intraperitoneally. at different time intervals, plasma and urine samples were collected. the binding affinity of sulfur mustard with urinary and plasma proteins and enzymes was studied for the first time using non-ideal ...

objective(s) bone is a dynamic tissue that is continuously renewed throughout life by the process of bone remodeling. antioxidant system might be involved in the pathogenesis of bone loss, so the aim of this study was to evaluate the total antioxidant capacity (tac), vitamin c and vitamin e levels of plasma besides measuring enzymatic antioxidants, superoxide dismutase (sod), catalase (cat) and...

organophosphate (ops) compounds are widely used in intensive agriculture to improve production, protect crops and control diseases vectors. the main mechanism of toxicity of ops is the inhibition of the cholinesterase enzymes. in this study the acetylcholinestrase (ache), butyrylcholinesterase (bche) and specific acetylcholinestrase (sache) activities as potential biomarkers of exposure to ops ...

A 68-year-old man on chronic hemodialysis for 6 years, presented with a spontaneous psoas muscle hemorrhage. Investigations showed intermittently elevated activated partial-thromboplastin time and thrombin time. Preliminary investigations suggested a heparin-like inhibitor in the patient's plasma, but no anti-Xa activity could be detected. Investigation of the ability of patient plasma to inhib...

The mechanisms underlying increases in the activity of various enzymes in the serum or plasma are, in general, incompletely understood. It has been stated that the plasma enzymes are derived from cellular elements either in the tissue or in the blood and that the level of circulating enzymes is therefore an index of the rate of disintegration of such cells (8). On the other hand, in some instan...

background: superoxide radicals are produced during oxidative metabolic processes, and removed by superoxide dismutase (sod) enzymes. controversial results have been reported regarding the tissue and plasma concentration of sod in patients with breast cancer. methods: venous blood was obtained from study participants and activity of sod enzyme was determined in 100 women. comparison was made be...

Abstract Background Bisphenol A (BPA) causes environmental pollution and is used as a natural antioxidant to protect against chemical side-effects. Costus well-known medicinal plant containing several biologically active compounds. We investigated the protective effects of costus extract toxic BPA in rat testes. Results Biochemical immunohistochemical investigations revealed that bisphenol redu...

The heme oxygenase (HO) and nitric oxide synthase (NOS) enzymes generate the gaseous signaling molecules carbon monoxide (CO) and nitric oxide, respectively. Constitutive NOSs localize to caveolae, and their activities are modulated by caveolin-1. Nothing is known of the localization of the inducible heme oxygenase-1 (HO-1) in plasma membrane caveolae. Thus, we examined the distribution and sub...

Reactive oxygen species and lipid peroxidation are important factors that contribute to the development of age-related cataract. The study included 130 patients with age-related cataract, 69 of whom were diagnosed with hypertension (HT), 20 with hypertension and type 2 diabetes mellitus (DM), and 41 had no accompanying condition. The following parameters were measured in the serum of the examin...