In this research study, the effect of baclofen (GABAB receptor agonist) on mean concentration of growth hormone, thyroxine, and triiodothyronine was examined. For this purpose, twelve Holstein Cows were divided into four groups. Then, each cow received daily injection of 25, 50, 75, and l00 mg/kg of baclofen for a period of four days. Blood samples were daily collected at one time point for eig...

background: the purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid (mpa) in iranian kidney transplant patients. methods: plasma mpa concentration of mycophenolate mofetile (mmf) 1 gram two times a day was measured in 21 iranian kidney transplant recipients receiving treatment. patients who entered the study had been transplanted for more than 3 months ...

licorice is obtained from glycyrrhiza glabra (g. glabra) in iran. glycyrrhizin is the main constituent of g. glabra and has several pharmacological effects. it is hydrolyzed to glycyrrhetic acid (ga) in the intestine after oral administration. in this study, a novel hplc method was used to determine the concentration of ga in rat plasma after oral administration of licorice aqueous extract. the...

introduction: repeated hyperglycemia play an important role in the development of atherosclerosis in diabetic patients. endothelium is the organ of the first-line defense against atherosclerosis and nitric oxide has a major role in this task. the aim of this study was to determine changes in plasma nitric oxide metabolites concentration during glucose tolerance test in type 2 diabetic rats. met...

background: malaria remains the world’s most devastating human parasitic infection. our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (fansidartm, halfantm, quinine, coartemtm and chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (hb aa, hb as and hb ss). materials and methods: spectrophotometric metho...

a comparative study on the effect of erythromycin and ivermectin on abomasal emptying in holstein-friesian calves motilides namely erythromycin have a great ability to increase abomasal emptying rate. the aim of this study was to evaluate the abomasal emptying rate in calves receiving either erythromycin or ivermectin. five male holstein-friesian calves were given each of the following 4 treatm...