the present work compared the clinical efficacy of ropically applied vitamin d3 (cholecalciferol), i a, 25 dihydroxy vitamin d3 (cakitriol) with calcipotriol (dovonex} in the treatment of plaque psoriasis. a randomized, double - blind, left - right, vehicle controlled study to assess the therapeutic efficacy and safety of mice daily application of 1 pg/g and 5 fj.g1g chalecakiferol. 1 pglg calc...

BACKGROUND Psoriasis, a chronic inflammatory disease associated with an accelerated risk of myocardial infarction, provides an ideal human model to study inflammatory atherogenesis in vivo. We hypothesized that the increased cardiovascular risk observed in psoriasis would be partially attributable to an elevated subclinical coronary artery disease burden composed of noncalcified plaques with hi...

BACKGROUND • Plaque psoriasis is a lifelong chronic, inflammatory skin condition that affects approximately 2.9% of the adult population in Italy.1 • Apremilast is an orally administered, small-molecule phosphodiesterase 4 inhibitor. It has a novel mechanism of action, targeting multiple steps in the pathogenesis of psoriasis. The marketing authorisation from the European Medicines Agency for t...

Psoriasis is a chronic inflammatory skin disease. It is assumed that the plaque phenotype of psoriasis is associated with T helper (Th) 1 immune response activation, while the guttate phenotype is associated with the Th17 immune response. Previous investigations of differences in the serum levels of cytokines relative to the clinical psoriatic phenotype have yielded conflicting results. This st...

BACKGROUND Although phenotypic heterogeneity of psoriasis is suggested by the alternate activation of either T-helper (Th)1-related or Th17-related cytokines, little is known about the mRNA levels of inflammatory cytokines. OBJECTIVE To investigate whether there is differential expression of Th1-related and Th17-related inflammatory cytokine genes 1) between psoriatic patients and healthy con...

OBJECTIVE To assess the efficacy of Methotrexate in patients with plaque type psoriasis. METHODS This descriptive study was conducted in the department of Dermatology, Civil Hospital Karachi from September 2009 to March 2010. Seventy three patients between 18 to 50 years of age suffering from plaque type psoriasis with PASI score of >10 were included in the study after taking the informed con...

In the paper, we focus on the chronic plaque psoriasis. It has the following characteristics. It is a well-defined plaque that is the most common presentation of psoriasis. Lesions can appear anywhere on the cutaneous surface. They enlarge to a certain size and then tend to remain stable for months or years. A temporary brown, white, or red macula remains when the plaque subsides. Typical image...

Because nail psoriasis is difficult to treat, therapy with many biological drugs has been attempted. Ustekinumab is approved for chronic plaque psoriasis and psoriatic arthritis (PsA), with some trials reporting nail improvement using this agent. A 51-year-old man with severe chronic plaque psoriasis had severe involvement of all fingernails and toenails, with accompanying nail fold psoriasis. ...

Pruritus was assessed in plaque psoriasis, atopic eczema and acne vulgaris using visual analogue scales. The results demonstrate that itch is a common and frequently troublesome symptom in plaque psoriasis. This observation should be more widely recognised in textbooks and publications.