Inflammation, Endothelial Permeability, and the Vulnerable Plaque The past 10 to 15 years have witnessed a tremendous interest in developing and validating noninvasive imaging techniques aimed at quantifying features of atherosclerotic plaque vulnerability in humans, most notably plaque inflammation. Among these, magnetic resonance imaging (MRI) with iron oxide nanoparticles has been widely inv...

Inflammation, Endothelial Permeability, and the Vulnerable Plaque The past 10 to 15 years have witnessed a tremendous interest in developing and validating noninvasive imaging techniques aimed at quantifying features of atherosclerotic plaque vulnerability in humans, most notably plaque inflammation. Among these, magnetic resonance imaging (MRI) with iron oxide nanoparticles has been widely inv...

Background—Atherosclerotic plaque at the carotid bifurcation is often associated with transient ischemic attack (TIA) and ischemic stroke, but the mechanisms are not completely understood. Previous histological studies have been too small or insufficiently detailed to reliably determine the temporal course of features of plaque instability or to stratify analyses by the nature of presenting sym...

BACKGROUND Atherosclerotic plaque at the carotid bifurcation is often associated with transient ischemic attack (TIA) and ischemic stroke, but the mechanisms are not completely understood. Previous histological studies have been too small or insufficiently detailed to reliably determine the temporal course of features of plaque instability or to stratify analyses by the nature of presenting sym...

Background and Aims: Patients with FH showed impaired immunosuppressive response associated increased inflammation. We tested Adoptive Cell Therapy (ACT) Treg engineered to selectively migrate in the atherosclerotic plaque dampen immune-inflammatory arterial wall.

The hypothesis of atherosclerosis as an inflammatory process has been a leitmotiv in cardiology for the past 20 years, and has now led to the launch of clinical trials aimed at testing whether drugs that primarily target inflammation can reduce cardiovascular events. Inflammation indeed drives all phases of atherosclerosis, from inception, through progression, and ultimately acute thrombotic co...

Inflammation plays a major role in all phases of atherosclerosis. Stable plaques are characterized by a chronic inflammatory infiltrate, whereas vulnerable and ruptured plaques are characterized by an "active" inflammation involved in the thinning of the fibrous cap, predisposing the plaque to rupture. Although a single vulnerable atherosclerotic plaque rupture may cause the event, there are ma...

A strong relationship exists between the severity of carotid stenosis and early stroke risk. Inflammation is believed to be an important event for atherosclerotic plaque destabilization and subsequent thromboembolism. (18)F-FDG can image atherosclerotic inflammation, providing information about plaque biology, which may serve as a useful biomarker for the assessment of early stroke risk.

BACKGROUND Cardiovascular morbidity and mortality is very important in patients with chronic renal failure. This occurs even in mild impairment of renal function and may be related to oxidative stress and chronic inflammation. The nephrectomized apo E knockout mouse is an accepted model for evaluating atherosclerosis in renal dysfunction. Erythropoietin derivates showed anti-oxidative and anti-...