Cell death is an important aspect of atherosclerotic plaque development. Insufficient efferocytosis cells by phagocytic macrophages leads to the buildup a necrotic core that impacts stability plaque. Furthermore, in presence calcium and phosphate, apoptotic bodies resulting from can act as nucleation sites for formation phosphate crystals, mostly form hydroxyapatite, which calcification plaque,...

Subendothelial accumulation of low-density lipoprotein (LDL) in arterial walls is an initiator of atherosclerotic plaque formation. We report here on the correlation between healthy state subendothelial LDL concentration distribution and sites of subsequent plaque formation in coronary arteries of patients with coronary artery disease (CAD). We acquired left (LCA) and right coronary artery (RCA...

Kumar A, Kar S, Fay WP. Thrombosis, physical activity, and acute coronary syndromes. J Appl Physiol 111: 599–605, 2011. First published May 19, 2011; doi:10.1152/japplphysiol.00017.2011.—Acute coronary syndromes (ACS) are common, life-threatening cardiac disorders that typically are triggered by rupture or erosion of an atherosclerotic plaque. Platelet deposition and activation of the blood coa...

objective(s):atherosclerosis is chronic inflammatory process triggered by oxidative stress. oxidative stress can increase hydrogen peroxide (h2o2)level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (pvat), foam cells, and atherosclerotic plaque. antioxidant is needed to control negative effects of oxidative stress. one source of antioxidant...

OBJECTIVE One of the major complications of diabetes is blood vessel disease, termed angiopathy, which is characterized by abnormal angiogenesis. The objective of this study was to discuss the characteristics of lower limb vascular angiopathy and plaque formation in type 2 diabetes patients and finding its relevance to the carotid atherosclerotic plaque formation, thus directing the clinical di...

Atherogenesis comprises three stages, including intimal thickening, plaque formation and destabilization and rupture of the plaque. Intimal thickening develops depending upon aging and is characterized by increased collagenous matrix. Plaque formation is characterized by an accumulation of intraand extracelluar lipids in intima, resulting in the advanced lesion with atheroma. Finally, advanced ...

Periodontal disease results from chronic bacterial infection caused by supragingival and subgingival plaque. Plaque is an acquired soft deposit that develops on the teeth, gums, and other structures in the oral cavity. The development and progression of periodontal diseases can be prevented by methods that control plaque formation. In addition, these measures can improve overall oral health and...

A clear relationship between diabetes and cardiovascular disease has been established for decades. Despite this, the mechanisms by which diabetes contributes to plaque formation remain in question. Some of this confusion derives from studies in type 2 diabetics where multiple components of metabolic syndrome show proatherosclerotic effects independent of underlying diabetes. However, the hyperg...

Atherosclerosis, the leading death in the United State, is a disease in which a plaque builds up inside the arteries. As the plaque continues to grow, the shear force of the blood flow through the decreasing cross section of the lumen increases. This force may eventually cause rupture of the plaque, resulting in the formation of thrombus, and possibly heart attack. It has long been recognized t...