A stability-indicating liquid chromatography method for the determination of the antifungal agent butenafine hydrochloride (BTF) in a cream was developed and validated using the Plackett-Burman experimental design for robustness evaluation. Also, the drug photodegradation kinetics was determined. The analytical column was operated with acetonitrile, methanol and a solution of triethylamine 0.3%...

Dextran a bacterial exopolysaccharide and a polymer of glucose is produced by different microorganisms like Leuconostoc mesenteroides, Lactobacillus spp, Streptococcus mutans, Weissella confusa etc. It has a wide range of applications in the food, pharmaceutical and other industries. Dextran and its derivatives like iron dextran, clinical dextran, food grade dextran are rapidly emerging as new ...

Response surface methodology was applied to optimize medium constituents for enzymatic production of L-cysteine from DL-2-amino-D-thiazoline-4-carboxylic acid (DL-ATC) by a novel Pseudomonas sp. Zjwp-14. With the Plackett-Burman design experiment, glycerol, DL-ATC, yeast extract, and pH were found to be the most powerful factors among the eight tested variables that influence intracellular enzy...

The analysis of rank ordered data has a long history in the statistical literature across diverse range applications. In this paper we consider Extended Plackett-Luce model that induces flexible (discrete) distribution over permutations. parameter space is combination potentially high-dimensional discrete and continuous components presents challenges for interpretability also posterior computat...

The incidence of a high percentage of negative rose bengal test (~BT~ sera which showed a high titre in the serum agglutmat10n (SAT) and complement fixation tests. (CFf). was noted in certain batches of sera during routme testmg for bo~ine brucellosis. As a similar phe~omenon has not previously been recorded, an investigation was undertaken to establish whether in this case a prozone reaction l...

Box and Hunter (1961) made an important observation that any fractional factorial design of resolutionR has the property that when projected onto anyR 1 factors it becomes a full factorial design. This has a signi cant implication for statistical analysis. We observe that the Plackett-Burman and related designs have a hidden projection property with an analogous implication for the analysis. Be...

We study the problem of online rank elicitation, assuming that rankings of a set of alternatives obey the Plackett-Luce distribution. Following the setting of the dueling bandits problem, the learner is allowed to query pairwise comparisons between alternatives, i.e., to sample pairwise marginals of the distribution in an online fashion. Using this information, the learner seeks to reliably pre...

This paper introduces two new methods for label ranking based on a probabilistic model of ranking data, called the Plackett-Luce model. The idea of the first method is to use the PL model to fit locally constant probability models in the context of instance-based learning. As opposed to this, the second method estimates a global model in which the PL parameters are represented as functions of t...

a solid state fermentation method was used to utilize wheat straw as substrates for citric acid production by using aspergillus niger atcc 9142. the plackett burman design (pbd) of experiments was used to test the relative importance of the variables affecting production such as moisture content, age of spore, inoculum size, initial ph of substrate, methanol concentration, incubation temperatur...