With treatment to remission as the gold standard for depression treatment, there is considerable reassessment of treatment approaches with the view to finding and employing agents capable of rapidly eliminating all symptoms and returning patients to normalcy. The selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressants, have a single-action mechanism involve...

Selective serotonin reuptake inhibitors (SSRIs) are a widely prescribed class of antidepressants. Laboratory and epidemiologic evidence suggests that a prolactin-mediated mechanism secondary to increased serotonin levels at neuronal synapses could lead to a potentially carcinogenic effect of SSRIs. In this population-based case-control study, we evaluated the association between SSRI use and br...

The controlled studies of selective serotonin reuptake inhibitors (SSRIs) in pediatric psychopharmacology research lag behind the controlled studies of SSRIs in adults. As a result, widespread use of SSRIs in the treatment of child and adolescent psychiatric disorders is in stark contrast to the paucity of research data. Recent changes in the research climate (including support from the Nationa...

aim and background: considering the high frequency of anxiety and depressive symptoms in irritable bowel syndrome (ibs) patients, selective serotonin reuptake inhibitors (ssris) are recommended by some gastroenterologists for treatment. in this study, the efficacy of fluvoxamine on severity of symptoms and quality of life in ibs patients was assessed. methods and materials: a randomized, double...

Clinical impact ratings Mental health wwwwwwq Psychiatry wwwwwwq Paediatrics wwwwwwq GP/FP/Primary care wwwwwwq . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Q Are selective serotonin reupt...

Fluoxetine and its successors (Table 1) differ from the heterocyclic antidepressants in that they inhibit serotonin reuptake, with little or no effect on other receptor sites. As a result of this specificity, these agents are referred to as selective serotonin reuptake inhibitors (SSRIs). Their clinical efficacy is believed to be the result of an initial increase in serotonin concentrations (in...

The selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed antidepressant drugs, because they are well tolerated and have no severe side effects. They rapidly block serotonin (5-HT) reuptake, yet the onset of their therapeutic action requires weeks of treatment. This delay is the result of presynaptic and postsynaptic adaptive mechanisms secondary to reuptake inhibit...

In this report, recommendations for the pharmacological treatment of anxiety and obsessive-compulsive disorders are presented, based on available randomized, placebo- or comparator-controlled clinical studies. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for panic disorder. Tri2-cyclic antidepressants (TCAs) are equally effective, but they are less well tolerated...

Depression is a serious illness that affects 20.9 million Americans a year. The most common method of treatment is selective serotonin reuptake inhibitors (SSRIs). Previous studies have shown that SSRI efficacy is limited. This review of current clinical data combined with statistical analyses has shown that the efficacy of SSRI treatment in adolescents is even more limited. It also has shown t...