BackgroundBerotralstat (BCX7353) is a recently approved, oral, once-daily kallikrein inhibitor for hereditary angioedema (HAE) prophylaxis. In the APeX-2 trial, berotralstat reduced HAE attack rates over 24 weeks, with favorable safety and tolerability profile.ObjectiveEvaluate safety, tolerability, effectiveness 48 weeks.MethodsAPeX-2 phase 3, parallel-group, multicenter trial (NCT03485911) in...

The aim of this study was to investigate the influence ADORA2A and CYP1A2 genotypes on physiological ergogenic effects caffeine. Sixty-six male cyclists were screened for genotypes; with 40 taking part subsequently in a randomised, double-blind, placebo-controlled study. Trial 1 used establish oxygen uptake?power output relationship maximal uptake. In trials 2 3, participants ingested 5 mg·kg ?...

primary dysmenorrhea is a prevalent issue and it can reduce the quality of life in many females worldwide. based on the properties of teucrium polium as a herbal medicine with analgesic and inflammatory properties, this triple-blind, randomized, placebo controlled trial was performed. the study aimed to evaluate the effects of teucrium polium on the severity of primary dysmenorrhea in students....

how to cite this article: abbaskhanian a, ehteshami s, sajjadi s, rezai ms. effects of piracetam on pediatric breath holding spells: a randomized double blind controlled trial. iran j child neurol autumn 2012; 6(4): 9-15.   abstarct: objective breath holding spells (bhs) are common paroxysmal non-epileptic eventsin the pediatric population which are very stressfull despite their harmlessnature....

background and aims: osteoarthritis is one of the most common arthritis in elderly. we evaluated to compare the effect of topical application of eugenia caryophylata extract and topical diclofenac in primary knee osteoarthritis.methods: this randomized double-blind clinical trial study was carried out upon 105 patients with primary knee osteoarthritis. patients were selected randomly and divide...

to investigate the effect of vitamin e supplementation on the response of intercellular adhesion molecule-1 (icam-1) to exhaustive exercise, 16 active men were selected and divided into supplementation and placebo groups based on vo2max. the subjects in each group completed 65 minutes of exhaustive exercise after14 days of supplementation. blood samples were collected before supplementation and...

Objective: To evaluate the efficacy and safety of AbobotulinumtoxinA (ABO) dose escalation in correction moderate-to-severe glabellar lines. Design: Phase 2, 36-week, multicenter, randomized, dose-ranging, double-blind, placebo-controlled study. Methods: Adults with lines received a single ABO treatment, dosed at 50, 75, 100, or 125 U, placebo. Primary endpoint was week 4 composite ≥2-grade res...

Background Cenerimod is an orally active, selective sphingosine 1-phosphate (S1P) 1 receptor modulator under investigation for the treatment of systemic lupus erythematosus (SLE). The Phase 2 CARE study ( NCT03742037 ) did not meet its primary endpoint after adjustment multiplicity, but patients treated with cenerimod 4 mg showed reduced disease activity versus placebo 6 months. [1] Along prior...

as the most common male sexual disorder premature ejaculation (pe), also referred to as early ejaculation (ee) or rapid ejaculation (re), affects 30%-40% of sexually active men. despite the limited number of available studies comparing the efficacy of selective serotonin re-uptake inhibitors (ssri) they have been thought to have beneficial effects for the treatment of patients with pe. in the p...