objective(s) the present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme q10 (coq10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (icv-stz), an animal model of sporadic type of alzheimer's disease. materials and methods the lesion groups were injected bilaterally with icv-stz (1.5 mg/kg b.wt., in no...

background: alzheimer’s disease was known as a progressive neurodegenerative disorder in the elderly and is characterized by dementia and severe neuronal loss in the some regions of brain such as nucleus basalis magnocellularis. it plays an important role in the brain functions such as learning and memory. loss of cholinergic neurons of nucleus basalis magnocellularis by ibotenic acid can commo...

introduction: zinc is an essential trace element that plays an important role in synaptic plasticity and modulating the activity of cns and involve in learning and memory. synaptic vesicle zinc in the hippocampus area exerting modulatory effects on nmda glutamate receptor. method: in this experiment the effects of nmda agonist and antagonist administration intra hippocampus on passive avoidance...

a b s t r a c t introduction: diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. due to anti-diabetic and antioxidant activity of rumex patientia (rp), this research study was conducted to evaluate the efficacy of chronic rumex patientia feeding on alleviation of learning and memory disturbance in streptozo...

There are several conflicting evidences showing the effect of morphine on learning and memory processes. In the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using Passive Avoidance shuttle box and Morris Water Maze tasks were investigated, respectively. Male rats received morphi...

There are several conflicting evidences showing the effect of morphine on learning and memory processes. In the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using Passive Avoidance shuttle box and Morris Water Maze tasks were investigated, respectively. Male rats received morphi...

introduction: butylated hydroxytoluene (bht 2, 6-di-tert-butyl-p-cresol) is one of the extensively used antioxidants in the food industry. it is used in low-fat foods, fish products, packaging materials, paraffin, and mineral oils. bht is also widely used in combination with other antioxidants such as bha, propyl gallate, and citric acid for the stabilization of oils and high-fat foods. on the ...

background and objective: based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid b on lessening of learning and memory deficits in streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats were allocated into control, salvialonic acid b-trea...

materials and methods thirty-two adult male wistar rats were randomly allocated to four groups: normal, diabetic, normal + extract of c. mukul and diabetic + extract of c. mukul groups with free access to regular rat diet. diabetes was induced in male rats by single interaperitoneal injection of 60 mg/kg stz. after the confirmation of diabetes, 300 mg/kg c. mukul extract was orally administered...