In the trinuclear title compound, [Zn(3)Cl(6)(C(13)H(20)N(4))(2)]·2H(2)O, each terminal Zn(II) atom is coordinated by an N(3) donor set from the Schiff base ligands and two Cl atoms in a distorted square-pyramidal geometry. The central Zn(II) atom is tetra-hedrally coordinated by two piperazine N atoms from two Schiff base ligands and two Cl atoms. The piperazine rings adopt chair conformations...

The mol-ecule of the title compound, C(28)H(28)N(2)O(6)P(2), is organized around an inversion center located at the centre of the piperazine ring. Both piperazine N atoms are substituted by P(O)(OC(6)H(5))(2) phospho-ester groups. The P atoms display a slightly distorted tetra-hedral environment; the N atoms show some deviation from planarity. The O atoms of the P=O groups are involved in inter...

We have designed imidazolium and piperazinium salts of pyropheophorbide-a in order to develop effective photosensitizers which have good solubility in polar and non polar media and to reveal the possible influences of the piperazine and imidazole moieties on the biological activities of pyropheophorbide-a. The phototoxicity of those pyropheophorbide-a salts against A549 cells was studied in vit...

Seed oils of Passiflora edulis, Jatropa curucas, Tinospora cordifolia, Sesbania grandiflora and Sapindus laurifolia were investigated for their antihelmintic property against Pheritima pasthuma. Three concentrations (10, 50 and 100 mg/ml) of each oil were studied in the bioassay, which involved the determination of time of paralysis and time of death of the worm. Sesbania grandiflora showed the...

In a search for new bactericidal and fungicidal agents some new piperazine-TV, TV'-bis-substituted derivatives have been prepared and characterized by their elemental analysis, IR, *H N M R , and mass spectral d a t a . T h e ant ibacter ia l and antifungal activities of all p repared c o m p o u n d s have been determined using Gentamycin as s t a n d a r d antibiotic. Some c o m p o u n d s s...

In the title salt, C11H17N2O2S(+)·CF3COO(-), the cation is protonated at the secondary piperazine N atom. The dihedral angle between the benzene ring and the piperazine mean plane is 85.54 (10)°. In the crystal, cations and anions are connected by two types of strong N-H⋯O hydrogen bonds into chains extending along [101]. The chains are further assembled into (10-1) layers via stacking inter-ac...

A rapid analysis method of piperazine ferulate tablets by optic-fiber sensing technology with UV-vis absorption spectrum was established. Qualitative and quantitative data were obtained and compared by maximum and minimum wavelength, absorbance and contrast spectra. Similarity method was used to identify authenticity of drugs. The difference of contents measured by this method and UV determinat...

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., M.H., Y.T., H.H., M.H., R.R., S.K., M.M., Y.M.); Department of Technology and Ecology, Hall of Global Environmental Studies, Kyoto University, Kyoto, Japan (S.K., Y.M.); Sumitomo Dainippon Pharma Co., Ltd. (Y.T., K.H., T.K., J.T., H.N., R.N.); Division of Systems Med...

A structure-based virtual screening of over 400,000 small molecules against the constitutive proteasome activity followed by in vitro assays led to the discovery of a family of proteasome inhibitors with a sulfonyl piperazine scaffold. Some members of this family of small non-peptidic inhibitors were found to act selectively on the β2 trypsin-like catalytic site with a preference for the immuno...

The anthelmintic activity of different extracts of nuts of Semecarpus anacardium were evaluated separately on adult Indian earthworm (Pheritima posthuma). It was found that petroleum ether, chloroform extract of S. anacardium (PESA and CESA, respectively) showed better anthelmintic activities than ethanol (EESA) and aqueous (AESA) extract of it. The anthelmintic effects of PESA and CESA at 10 m...