Present study reports CNS depressant and analgesic activities of methanol extract obtained from the leaves of Piper longum L (MEPL). CNS depressant activity was evaluated by using open field and hole cross tests at doses of 250 and 500 mg/kg body weight while peripheral analgesic activity was evaluated by using acetic acid induced writhing method and formalin test respectively in rat model at 1...

Epilepsy affects 5 to 10 per 1000 of the general population. It is the third most common neurological disorder after stroke and Alzheimer's disease. Available anti-convulsant drugs effectively control epilepsy in about 50% of the patients. Many epileptic seizures are refractory to current anti-epileptic drugs and safety of the anti-epileptic drugs has always been a concern. Herbal drugs may ser...

Ethanolic extracts of six Indian medicinal plants, piperine, guggulsterone E and guggulsterone Z were tested for cytotoxicity using brine shrimp lethality test. Piper longum showed most potent cytotoxic activity. Piperine, guggulsterone E and guggulsterone Z showed potent activity with LC(50) 2.4, 8.9 and 4.9, respectively.

Thailand is located in the tropical rain forest zone above the equator. This geographically supports very rich biodiversity, including the genus Piper (Piperaceae). Thirtyeight species of Piper, from out of over 1,000 species in the world, have been discovered recently (1998-2006) by the authors. Plant morphology and plant use information were recorded via observation, market surveys, and inter...

In this study the attempt was made to evaluate the antimicrobial activity of various solvent extracts of fruit of Piper longum L. against different gram positive and gram negative bacteria by using disk diffusion method. The petroleum ether extract was resistant towards all the tested bacterial strains while ethyl acetate was highly active. Among all the gram positive bacteria Staphylococcus au...

tuberculosis, M. bovis, M. africanum and others, known collectively as the M. tuberculosis complex (MTC) [1]. M. tuberculosis is responsible for more human mortality than any other single microbial species [2]. According to estimates by World Health Organization (WHO), almost 9 million new cases and 1.4 million TB deaths occurred in 2011 [3]. Although there are effective anti-tubercular agents,...

Piper interruptum Opiz. and Piper chaba Linn. are herbaceous plants in the Piperaceae family. The ethanol extract of P. interruptum and P. chaba inhibited ethyl phenylpropiolate-induced ear edema and carrageenan-induced hind paw edema in rats. Both extracts reduced transudative and granuloma weights as well as body weight gain and thymus weight of the chronic inflammatory model using cotton pel...