the study was undertaken to answer the question that how many patients with pigmentation of back and arms actually have amyloid deposits in pathology. 44 patients presenting with diffuse pigmentation of back and arms (dpoba) were selected. skin biopsies were performed in all cases from the affected sites. on all formalin fixed and paraffin embedded specimens, the following histochemical stains ...

BACKGROUND The purpose of this study was to determine the prevalence of childhood dermatoses in Diyarbakir, which is located in the southeastern region of Turkey. MATERIAL AND METHOD This cross-sectional study was carried out in April 2008 among students of eight randomly selected public primary schools in Diyarbakir. Students were examined and questionnaire was applied to determine socioecon...

Melatonin, the evolutionarily ancient methoxyindoleamine, has long captured attention of investigators since discovery its regulation mammalian fur and amphibian skin pigmentation, as well extrapineal synthesis receptor expression in human skin. Yet, melatonin’s role impact on melanocyte physiology remain unclear. Therefore, we asked whether melatonin stimulates or inhibits epidermal pigmentati...

Laugier-Hunziker syndrome is characterized by idiopathic mucocutaneous pigmentation that may be associated with longitudinal melanonychia. The significance of this condition is due to its inclusion in differential diagnoses of pigmentary disorders of the oral mucosa, especially Peutz-Jeghers syndrome.

The mechanistic Target of Rapamycin Complex 1 (mTORC1) exerts multiple physiological functions, including nutrient sensing and the control metabolism, proliferation, senescence Wnt signaling. Yet, role mTORC1 activity in human hair follicle (HF) biology remains unknown. Since patients with a loss-of-function mutation key endogenous inhibitor activity, tuberous sclerosis complex (TSC), can show ...

Aims: Pigmentation disorders are one of the main skin problems due to mustard gas exposure in chemically-injured veterans. The aim of this study as part of the Sardasht cohort study was to investigate the association between IL-6 and IL-4 and pigment disorders in chemically-injured veterans exposed to mustard gas. Materials & Methods: In this study, 500 subjects including 372 people expose...

Nail melanoma (NM) must be suspected in the initial workup of patients with pigmented nails. However, differential diagnosis NM from other nail disorders that involve pigmentation is challenging. Dermoscopic, clinical, and histopathological features are integrated for a definite diagnosis. The primary treatment surgery. Depending on depth invasion, amputation or functional surgery can chosen. T...

There is a continual need to develop novel and effective melanogenesis inhibitors for the prevention of hyperpigmentation disorders. The plant Artemisia capillaris Thunberg (Oriental Wormwood) was screened for antipigmentation activity using murine cultured cells (B16-F10 malignant melanocytes). Activity-based fractionation using HPLC and NMR analyses identified the compound 4,5-O-dicaffeoylqui...

Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders. In daily practice, dermoscopy may confirm clinical diagnoses and guides in the management of nail diseases and treatments, permitting a better visualization of symptoms. Dry dermoscopy is required for evaluation of the nail plate surface, while...