Marein is the main active substance of Coreopsis tinctoria nutt. It not only has anti-oxidation and anti-tumor effects, but also can lower blood lipid, prevent high glucose, improve insulin resistance, inhibit gluconeogenesis promote glycogen synthesis. However, exact mechanism its action still unclear. Here, we explored effect on resistance. The mice were divided into db/m, db/db, metformin+db...


 Purpose: To study the influence of oxymatrine on hypoxic-ischemic brain injury (HIBI) in neonatal rats.
 Methods: Newborn SPF Sprague-Dawley (SD) rats were randomly assigned to 3 groups (10 rats/group): control, HIBI and groups. Neurobehavioral latency each rat was determined after 48 h treatment, pathological changes cerebral cortex evaluated using H&E staining. Hippocampal neu...

Background: The PI3K/AKT/m TOR pathway is activated in gastric cancer (GC). This may be an appropriate target for GC therapy. Such therapy involve inhibiting cell proliferation, enhancing apoptosis, and restoring the sensitivity of cells to chemotherapy. Aim: To study expression PI3K/AKT/mTOR Egyptian patients with GC. Methods: Enrolled Patients were divided into 2 groups, group 1 included 23 l...

Background: Non-small cell lung cancer (NSCLC), caused by abnormal gene drive, may have primary drug resistance after treatment with tyrosine kinase inhibitors (EGFR-TKIs). Therefore, we explore whether the drug-resistant NSCLC treated EGFR-TKI is related to miR-21/Sonic Hedgehog (SHH)/PI3K/AKT pathway. Methods: The patients from our hospital who meet AJCC TNM staging (7th edition) stage IIIB a...

Purpose: To investigate the effect of forkhead box N3 (FOXN3) protein on doxorubicin (DOX) resistance urothelial carcinoma (BLCA).
 Methods: Bioinformatics prediction and immunoblotting were used to evaluate FOXN3 expression in BLCA tissues cells. The overexpression was achieved by cell transfection. effects DOX apoptosis determined immunoblotting, assay, flow cytometry, while applied SIRT...

Purpose: To investigate the influence of suppressor cytokine signaling 3 (SOCS3) on rats with colon cancer (CC).
 Methods: Sprague-Dawley (SD) were randomly divided into CC group and control group. models constructed. The expression SOCS3 in tissues was determined by quantitative real time-polymerase chain reaction (qRT-PCR). Hematoxylin-eosin staining (H&E) used to examine tissue morp...

The aim of this study was to explore the expression of PI3K, AKT, and P-AKT, and to investigate the role of PI3K/AKT signaling pathway in thin endometrium. We included 40 women treated in affiliated Shenzhen Nanshan People's Hospital of Guangdong Medical University for endometrial conditions between August 2013 and January 2015, 20 with a normal endometrium, and 20 with thin endometrium. The ex...

Purpose: To study the effects of anisodamine (Ad) combined with lidocaine (Ldc) on myocardial ischemia-reperfusion injury (MIRI) in rats, and its correlation PI3K/AKT signaling pathway.Methods: A total 70 healthy rats were randomly divided into S group, M Ad Ldc + LY group. The cardiac hemodynamic indices each group determined, area infarction measured. Serum biochemical also determined. Furthe...

Objective(s): Lung cancer is one of the most common malignant tumors, which seriously threatens the health and life of the people. Recently, a novel long non-coding RNA (lncRNA) termed lncFOXO1 was found and investigated in breast cancer. However, the effect of lncFOXO1 on lung cancer is still ambiguous. The current study aimed to uncover the functions of lncFOXO1 in l...

Objective(s): microRNA-29 (miR-29) family miRNAs have been mentioned as tumor suppressive genes in several human cancers. The purpose of this study was to investigate the function of miR-29a in nasopharyngeal carcinoma (NPC) cells. Materials and Methods: Human NPC cell line 5-8F was transfected with mimic, inhibitor or scrambled controls...