Gold nanoparticle-coated Pluronic-b-poly(L-lysine) nanoparticles (Pluronic-PLL@Au NPs) were synthesized via an easy one-step method and employed as carriers for the delivery of paclitaxel (PTX) in chemo-photothermal therapy, in which Pluronic-PLL acts as the reductant for the formation of AuNPs without the need for an additional reducing agent. METHODS The deposition of AuNPs on the surface o...

BACKGROUND Increasing resistance of oral pathogens to conventional antibacterial agents has resulted to find alternative therapies to overcome resistance development problems; hence this in vitro study was carried out to investigate the efficacy of photoelimination of Streptococcus mutans with two methods of photodynamic and photothermal therapy. METHODS Standard Suspensions of S. mutans were...

Chemodynamic-Photothermal Therapy In article number 2102759 by Liangliang Zhang, Shulin Zhao, Hong Liang, and co-workers, smart near infrared carbon dot-metal organic framework assemblies are developed for tumor microenvironment (TME)-activated cancer imaging chemodynamic-photothermal combined therapy.

Near-infrared light-responsive inorganic nanoparticles have been shown to enhance the efficacy of cancer photothermal ablation therapy. However, current nanoparticle-mediated photothermal ablation is more effective in treating local cancer at the primary site than metastatic cancer. Here, we report the design of a near-infrared light-induced transformative nanoparticle platform that combines ph...

A one-step synthesis of Prussian blue nanoparticles possessing a concentration gradient of Gd3+ counterions, g-Gd-PB, has been developed, and the potential for the particles to perform as both MRI positive contrast agents and photothermal therapy agents is demonstrated. The synthesis of potassium/gadolinium ironhexacyanoferrate is performed under increasing concentration of Gd3+ ions forming pa...

Single-walled carbon nanotubes (SWNTs) have a high optical absorbance in the near-infrared (NIR) region. In this special optical window, biological systems are known to be highly transparent. The optical properties of SWNTs provide an opportunity for selective photothermal therapy for cancer treatment. Specifically, CoMoCAT nanotubes with a uniform size (about 0.81 nm) and a narrow absorption p...

Multifunctional nanocomposites that have multiple therapeutic functions together with real-time imaging capabilities have attracted intensive concerns in the diagnosis and treatment of cancer. This study developed epidermal growth factor receptor (EGFR) antibody-directed polydopamine-coated Fe3O4 nanoparticles (Fe3O4@PDA NPs) for magnetic resonance imaging and antitumor chemo-photothermal thera...

Photothermal therapy has inspired numerous interests due to its minimal invasion, easy to perform, and possibilities to treat embedded tumors in vital regions. In this review, examples where various types of photothermal nanoagents including carbon-based, organic near-infrared dye-based, polymer-based nanomaterials have been utilized to converse near-infrared light energy to heating within tumo...

Cancer therapy with two different modalities can enhance treatment efficacy and reduce side effects. This paper describes a new method for combined chemo- and photothermal therapy of cancer using poly dopamine nanoparticles (PDA-NPs), where PDA-NPs serve not only as a photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a carrier to deliver ...

Photothermal-Gas Synergistic Cancer Therapy In article number 2206749, Benhui Hu, Yun Liu, and co-workers propose a cascade reaction-promoted CO release strategy to realize augmented photothermal-gas synergistic cancer therapy. Gold-based porphyrinic coordination polymer nanosheets synthesized by simple aqueous phase reaction, with ultrasmall zero-valent gold as the node, have advantages of hig...