A generalized skin eruption with strong itching was induced by sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, in a patient almost 6 months after initiation of the drug. Physical examination revealed a spread of skin rash from chest to back, and abdomen and thigh. Discontinuation of the drug eliminated the skin rash immediately. The emergence of new rash ended, and the rash itself with...

Background: Increasing knowledge regarding the deleterious effects of sun exposure and mechanisms photodamage has enabled development tailored photoprotection strategies based on skin type existence underlying conditions. Dermatologists play an essential role as they identify specific needs their patients. This translates into recommendations suitable protection measures, both in terms length t...

UV irradiation of the skin leads to the induction of free radicals, carcinogenesis, and skin aging, and thus the use of beta-carotene in humans as a chaperoning agent is discussed. In the photohemolysis model, beta-carotene protects against the phototoxic effects of porphyrins. Beta-carotene should be used in erythropoietic protoporphyria, photosensitive diseases, and to reduce the effects of p...

In a series of 2053 cases of epilepsy studied 3.9% were found to have some form of photosensitive epilepsy. The mean age of onset was 14.9 years for males, 11.8 years for females. In the age group of 6-10 years there was a definite male preponderance. In 48.2% cases the seizures were caused by watching television and in 7.4% they were precipitated by sunlight or electric lights. Primary general...

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease in which cutaneous lesions occur in 72%-85% of patients. Objective: This study was conducted to determine the pattern and incidence of skin lesions in SLE patients in Ahwaz. Patients and Methods: Thirty patients with SLE fulfilling the clinical and laboratory criteria of the American Rheumatism Association who were admitted...

Propionibacterium acnes is often discussed as a contri­ buting pathogenic factor in the aetiology of acne lesions. The aim of this study was to test which porphyrin pat­ terns are synthesized by P. acnes in vivo in untreated acne patients and during standard acne regimens. These photosensitive compounds are potential targets for photo­ dynamic therapy of acne and need to be better characte­ riz...

DNA damage is implicated in cancer and aging, and several DNA repair mechanisms exist that safeguard the genome from these deleterious consequences. Nucleotide excision repair (NER) removes a wide diversity of lesions, the main of which include UV-induced lesions, bulky chemical adducts and some forms of oxidative damage. The NER process involves the action of at least 30 proteins in a 'cut-and...

Dapsone, a potent anti-inflammatory compound, is mainly used in the treatment of leprosy, dermatitis herpetiformis, erythema elevatum diutinum and other dermatoses. Cutaneous adverse reactions range from acneiform eruptions to toxic epidermal necrolysis. A 30-year-old, married women who was treated with paucibacillary multi drug therapy, developed itchy skin lesions over the both forearms, 'V '...

We encountered a patient with methylmalonic aciduria associated with skin lesions resembling acrodermatitis enteropathica. This child was being fed with a low-protein diet when the skin disorder developed. A deficiency in plasma levels isoleucine, was confirmed. Supplementation of a high-caloric, protein-rich diet led to a prompt improvement of skin lesions. We assume that in our patient the sk...