In airway smooth muscle (ASM), ACh induces propagating intracellular Ca2+ concentration ([Ca2+]i) oscillations (5-30 Hz). We hypothesized that, in ASM, coupling of elevations and reductions in [Ca2+]i to force generation and relaxation (excitation-contraction coupling) is slower than ACh-induced [Ca2+]i oscillations, leading to stable force generation. When we used real-time confocal imaging, t...

Abstract In living systems, the formation of structures relies on balancing kinetic and thermodynamic influences powered by reversible covalent bond chemistry. Although synthetic efforts have replicated these processes to some extent, elucidating their combination is necessary identify mechanisms that confer nature’s structural precision flexibility within a complex environment. Here we design ...

Nitrous acid (HONO) is a key precursor to the principal atmospheric oxidant OH. HONO measurements during solar eclipse show little variation, implying main sources are photolytic, approximately balancing removal through photolysis.

Long-term increases in the strength of excitatory transmission at Schaffer collateral-CA1 cell synapses of the hippocampus require the insertion of new alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) into the synapse, but the kinetics of this process are not well established. Using microphotolysis of caged glutamate to activate receptors at single dendritic spines in hip...

high yield photolytic reduction of a series of thiaphosphoranes z p sr to give z p h with uv-light-induced tri-n-butyltin hydride through phosphoranyl radical z p is described. this reaction is inhibited by a-methylstyrene and initiated by a radical initiator such as azobisisobutyronitrile

Bloom et al. (1) found that ultraviolet light converted pteroylglutamic acid (PGA) which is not fluorescent into a fluorescent material. Stokstad, Fordham, and de Grunigen (2) observed that sunlight caused the liberation of a diazotizable amine, indicating that cleavage had occurred between the pterine and the p-aminobenzoylglutamic acid components. As part of a search for a sensitive analytica...