The diagnosis of lung cancer was significantly enhanced by the development of the fiberoptic bronchoscope in 1965. Since then, advances in photosensitizers and light sources have brought photodynamic medicine into the light. This article offers an historic overview of the emergence of photodynamic medicine through the perspective of a pioneer with more than 30 years' experience. Along with a di...

The photosensitizing action of dyes on biological systems is commonly designated as "photodynamic action." The subject has been well summarized in a monograph by Blum (1941). Earlier studies on photodynamic inactivation of bacteriophages were made by Clifton (1931), and by Perdrau and Todd (1933). Burnet (1933) discovered that the relative sensitivities of phage strains to photodynamic inactiva...

Recent decades have seen the inclusion of acne vulgaris as a potential new indication for photodynamic therapy. Photodynamic therapy and light sources can be considered to be additional tools for primary or adjunctive therapy in patients with recurrent acne or those in whom it is not possible to use other treatments. We investigated the use of pulsed dye laser plus methylaminolevulinate for pho...

introduction : halitosis is a common problem that affects a large portion of the population worldwide. the origin of this condition is oral in 90% of cases and systemic in 10% of cases. the foul odor is caused mainly by volatile sulfur compounds produced by gram-negative bacteria. however, it has recently been found that anaerobic gram-positive bacteria also produce hydrogen sulfide (h 2 s) in ...

Graphene and its derivatives such as graphene oxide (GO) have been widely explored as promising drug delivery vehicles for improved cancer treatment. In this review, we focus on their applications in photodynamic therapy. The large specific surface area of GO facilitates efficient loading of the photosensitizers and biological molecules via various surface functional groups. By incorporation of...

INTRODUCTION Vulvar intraepithelial neoplasia may lead to vulvar cancer. Vulvar cancer is a rare (accounting for about 2,5-5% of all malignant neoplasms), female genital organs cancer. Photodynamic therapy is a new treatment for a wide variety of malignancies and premalignant dysplasias. We wanted to examine the effectiveness of photodynamic therapy (PDT) on vulvar intraepithelial neoplasia (VI...

We report for the first time that organic nanoparticles with photodynamic activity and aggregation-induced emission characteristics are developed for targeted and image-guided photodynamic cancer therapy.

one The Roswell Park History of PDT: 1972 to the Present: A Personal Perspective, Thomas J. Dougherty ......................................................................1 two Principles of Photodynamic Therapy-Induced Killing of Tumor Cells, Nancy L. Oleinick and David Kessel .............................................................. 19 three PDT Laser Physics and Safety, Tom Mang .........

PURPOSE Loss of vascular barrier function has been observed shortly following vascular-targeting photodynamic therapy. However, the mechanism involved in this event is still not clear, and the therapeutic implications associated with this pathophysiologic change have not been fully explored. EXPERIMENTAL DESIGN The effect of vascular-targeting photodynamic therapy on vascular barrier function...

Photodynamic therapy seems to be able to control high-grade dysplasia within Barrett's esophagus about 80% of the time. Long-term results are not available, but the treatment is promising. Given the success with surgical intervention, however, use of photodynamic therapy should be reserved for nonsurgical candidates at the current time. The complications that occur with photodynamic therapy are...