We studied antegrade concealed conduction of atrial extrastimuli (A2) that blocked in the atrioventricular (AV) node in eight subjects, using a third extrastimulus (A3), coupled at decreasing coupling intervals to A2. Three A1-A2 intervals were tested in each subject: late (just shorter than AV nodal effective refractory period), intermediate, and early (just longer than atrial functional refra...

The impact of repeated administration cinntamtannin A2 (A2, 25 μg/kg) on skeletal muscle disuse atrophy model mice induced by hindlimb suspension for 14 days was examined. In soleus, weight loss and a reduction in the average myofibre size with shifting to smaller side peak were observed suspension-vehicle group, but reduced these changes. Average significantly increased ground-A2 compared grou...

Naegleria fowleri is a free-living amoeba, known as a causative agent for a fatal disease of the central nervous system (CNS) in man such as Primary amoebic meningoencephalitis (PAM). Factors contributing to its pathogenicity and its distribution in the environment have been investigated by previous researchers. In case of its pathogenicity, several enzymes such as phospolipase A and sphingomye...

ADP-ribosyl cyclase (ADPR-cyclase) produces a Ca(2+)-mobilizing second messenger cyclic ADP-ribose (cADPR) from NAD(+). In this study, we investigated the molecular basis of ADPR-cyclase activation and the following cellular events in angiotensin II (ANG II) signaling in mouse mesangial cells (MMCs). Treatment of MMCs with ANG II induced an increase in intracellular Ca(2+) concentrations throug...

Four reduced-height (5 m) BS 8414-1 façade flammability tests were conducted, three having mineral-filled aluminium composite material (ACM-A2) with polyisocyanurate (PIR) and phenolic (PF) foam stone wool (SW) insulation, the fourth polyethylene-filled ACM (ACM-PE) PIR insulation. Each was constructed from a commercial engineer’s design, built by practising installers. The ACM-PE/PIR burnt so ...

syntax n ∈ Num x ∈ Var a ∈ Aexp a ::= n | x | a1 + a2 | a1 * a2 | a1 a2 Semantic domains Integer = {... -3, -2, -1, 0, 1, 2, 3 ...} Truth-Value = {true, false} State = Var → Integer Semantic valuation functions N: Num → Integer A: Aexp → State → Integer A [[n]] = λs. N [[n]] A [[x]] = λs. s x A [[a1 + a2]] = λs. A [[a1]] s + A [[a2]] s A [[a1 * a2]] = λs. A [[a1]] s * A [[a2]] s 6 Prolog and Au...

Antiphospholipid (aPL) antibodies recognize receptor-bound beta(2) glycoprotein I (beta(2)GPI) on target cells, and induce an intracellular signaling and a procoagulant/proinflammatory phenotype that leads to thrombosis. Evidence indicates that annexin A2 (A2), a receptor for tissue plasminogen activator and plasminogen, binds beta(2)GPI on target cells. However, whether A2 mediates pathogenic ...

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Bleomycins, a group of glycopeptide antibiotics differ from one another in their terminal amine moieties. 14C-Methyl-labeled 3-aminopropyl-dimethylsulfonium was confirmed to be incorporated into the amine moiety of bleomycin A2. Addition of amines of bleomycin A2, A2'-a, A2'-b, A2'-c, A5, B2 and B4 to fermentation media increased the rate of production of the bleomycin which contained the added...