Antimitotic effects have been reported for several members of the class of compounds which may be described as the simple substituted phenols (Muhling et al., 1960, Hindmarsh 1951, Levan and Tjio 1948, Loveless and Revell 1949, Clowes 1951). Muhling et al. (1960) showed that complex derivatives such as the phenoxyalkyl acids exhibit an effect on mitosis similar to that of the phenols, and sugge...

A photoinduced reaction between TMDPO (diphenyl(2,4,6-trimethylbenzoyl)-phosphine oxide) and perfluoroalkyl iodides successfully affords P-(perfluoroalkyl)diphenylphosphines as promising ligands for recyclable catalysts. Interestingly, the perfluoroalkylation reaction involves the reduction of phosphorus(V) compounds to phosphorus(III) species. The advantages of the present reaction include the...

Previous studies (1, 2) have shown that the phosphorus metabolism of mouse tissues is markedly altered by leukemic infiltration, the absorption and retention of radio-phosphorus being increased in the tissues of leukemic animals. The present work goes one step further in elucidating the seat of this altered phosphorus metabolism by fractionating the tissues into the three broad groups of biolog...

In a 4-isopropyl-1-oxa-3-oxonia-2-borata-naphthalene the isopropyl group exhibits the same conformational phenomena as the Me2N group in 8-dimethylamino-naphth-1-yl-silanes and related phosphorus compounds. Since the details can be fully rationalized on the basis of the steric situation and electronic factors are excluded, the common features cannot serve to infer dative interaction from nitrog...

During the past 15 or 20 years our knowledge of the phosphorus content of the human blood has been considerably advanced by the work of several investigators. The inorganic phosphorus fraction, which is only about onetenith of the total phosphorus content of the whole blood, appears to have claimed the attention of most of the previous workers, and, therefore, abundant data are available from t...

Acute static bioassays were conducted with 13 pesticides to determine their comparative toxicity to fish. There was a wide range in the toxicity of these compounds with 96-hour TLm values ranging from 0.0033 to 4.0 mg/1. Of the compounds tested, Thiodan, a chlorinated hydrocarbon, and Thimet, an organic phosphorus pesticide, were the most toxic; and Bayer 29493, an organic phosphorus compound, ...

Biological productivity in many ocean regions is controlled by the availability of the nutrient phosphorus. In the Mediterranean Sea, aerosol deposition is a key source of phosphorus and understanding its composition is critical for determining its potential bioavailability. Aerosol phosphorus was investigated in European and North African air masses using phosphorus near-edge X-ray fluorescenc...

The phosphorus chemical shift tensors of two dithiadiphosphetane disulfides, 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-di sulfide (1) and 2,4-bis(methylthio)-1,3-dithia-2,4-diphosphetane-2,4-disu lfi de (2), have been characterized by solid-state 31P nuclear magnetic resonance (NMR) measurements. The weak homonuclear dipolar interaction between the two 31P nuclei in each of thes...

Synthesis of 8-phosphorus substituted isosteres of purine [pyrimidino (4,5-d)-1,3,2-diazaphosphole], 1-deazapurine [pyridino (2,3-d)-1,3,2-diazaphosphole] and 3-deazapurine [pyridino (4,5-d)-1,3,2-diazaphosphole] has been achieved by the reaction of equimolar amounts of triphenylphosphite and 4,5-diaminopyrimidine, 2,3-diaminopyridine and 3,4-diaminopyridine, respectively. These compounds hydro...