We isolated 8 novel 28-noroleanane-derived spirocyclic triterpenoids with unusual skeleton structures, phlomisone (1), phlomistetraol A (2), phlomistetraol B (3), phlomistetraol C (4), phlomispentaol (5), phlomishexaol A (6), phlomishexaol B (7), and phlomisin (8), from the ethanol extract of Phlomis umbrosa rhizomes. Their structures were elucidated on the basis of spectroscopic methods, inclu...

Obituary of insight into the mechanisms of myelination and of In Memoriam: neuronal–glial interactions. Wood, Dick established that the axon was mitogenic for Schwann cells and oligodendrocytes (Wood and Bunge, 1975, 1986), providing the first example of the biological The neuroscience community has lost a pioneer, a men-activity we now recognize as the neuregulin family of tor, and a generous ...

From the aerial parts of the plant Phlomis chimerae, a new neolignan glucoside, (-)-4-O-methyldihydrodehydrodiconiferyl alcohol-9'-O-beta-D-glucopyranoside (1) was characterized along with the known neolignan glucosides, (-)-4-O-methyldehydrodiconiferyl alcohol-9'-O-beta-D-glucopyranoside (= longifloroside A) (2) and (-)-dihydrodehydrodiconiferyl alcohol-9-O-beta-D-glucopyranoside (3). The stru...

Flavonoids from Trollius chinensis Bunge.(Flos Trollii) were extracted by different method were investigated in the present study. Simultaneous determination of two flavonoids(orientin and vitexin) was accomplished by a useful, rapid and simple HPLC/DAD-ESI-MS method. A central composite design (CCD) combined with response surface methodology(RSM) was used to study the effects of extraction tim...

The first barrier, when penetrating an insect host, encountered by microorganisms like fungi is insects cuticle; produce a wide variety of extracellular enzymes involved in the degradation protein, chitin, and lipids. main objectives were to assay enzymatic activity Cordyceps locustiphila anamorph, solid liquid medium at different temperatures also evaluate pathogenicity against South American ...