Thiosuccinimide-linked antibody-drug conjugates (ADCs) are susceptible to drug loss over time due to a retro-Michael reaction, which can be prevented by selecting stable conjugation positions or hydrolysis of the thiosuccinimide. Here, we investigate pyrrolobenzodiazepine (PBD) ADC drug-linkers equipped with N-phenyl maleimide functionality for stable thiol conjugation via thiosuccinimide hydro...

In the title co-crystal, C(3)H(7)NO(2)·C(9)H(10)O(3), the (S)-alanine mol-ecule exists in the zwitterionic form stabilized by two pairs of N(+)-H⋯O(-) hydrogen bonds and an electrostatic inter-action between the ammonium center and the carboxyl-ate anion, forming a sheet along the ab plane. The carboxyl group of the (S)-2-phen-oxy-propionic acid mol-ecule is connected to the top and bottom of t...

Four phenylalanine nitrogen mustards were tested against the S91 Cloudman mela noma in young male mice. Two of the mustards carried the di (2-chloroethyl) amino group in the meta position but differed in respect to the location of the amino group in the alanine side chain. Likewise, two of the mustards carried the di(2-chloroethyl)amino group in the para position, again differing, however, in l...

Phenylalanine amonia-lyase (PAL) is one of the most important enzymes that plays a key role in regulationof phenylpropanoid production in plants. It catalyzes the first step of the phenylpropanoid pathway in whichL-phenylalanine is deaminated to trans-cinnamic acid. This step is significant for metabolic engineering andhyper-expression of the major phenylpropanoid, methyl chav...

in current study, protein hydrolysates were produced using microbial proteases of alcalase, protamex and flavourzyme from yellowfin tuna viscera. the results indicated that, protein hydrolysate from alcalase, had significantly higher protein content, nitrogen recovery and degree of hydrolysis than the others (p 0.05). the results of amino acids composition revealed that all hydrolysates were al...

Aureobasidin A, a new antifungal antibiotic, was isolated from the culture medium of Aureobasidium pullulans R106. Aureobasidin A was a cyclic depsipeptide consisting of eight alpha-amino acid units and one hydroxy acid unit. The structures of the units were found by acid hydrolysis of the antibiotic to be 2(R)-hydroxy-3(R)-methylpentanoic acid, beta-hydroxy-N-methyl-L-valine, N-methyl-L-valine...

The effects of the antimalanal chug chloioqume (CQ) on aiachidonic acid (AA) hbeiation fiom tlnomboxane B 2 (TXB2) foimation m, and aggiega tion of isolated human polymoiphonucleai (PMN) leukocytes stimulated with Nfoimyl methionyl leucyl phenyl alanine (FMLP) weie investigated CQ decieased aggiegation of stimulated PMN leukocytes howevei m contiast to AA hbeiation and TXB 2 foimation lowei con...

The title hydro-chloride salt, C(18)H(21)N(2)O(+)·Cl(-), is an imidazolidinone catalyst, which was derived from L-phenyl-alanine through cyclization with acetophenone. The imidazolidinone compound has a five-membered heterocyclic ring including two chiral centres. The imidazolidinone ring displays an envelope conformation, with the flap protonated N atom lying 0.497 (3) Å above the mean plane o...

The effects of DL-fl-phenyl-,8-alanine (BPBA) on vagal efferent discharges elicited by y aminobutyric acid (GABA) and baclofen were investigated in rats. When given alone, BPBA (40 mg/kg, i.v.) caused no significant change in vagal nerve response and did not elicit any convulsions. Pretreatment with BPBA (40 mg/kg, i.v.) resulted in 70% and 80% reductions in the vagal efferent dis charges induc...