نتایج جستجو برای: phenanthridine

تعداد نتایج: 222  

Journal: :Chemical communications 2014
Ravi Kiran Chinnagolla Masilamani Jeganmohan

The highly regioselective ortho-arylation of acetanilides with aromatic boronic acids in the presence of a Ru(II) complex (3 mol%), AgSbF6 (12 mol%), Cu(OTf)2 (20 mol%) and Ag2O (1.0 eq.) is described. Later, ortho-arylated acetanilides were converted into phenanthridine and carbazole derivatives by using Ph3PO and Tf2O or palladium or Cu(OTf)2 catalysts.

Journal: :Chemical & pharmaceutical bulletin 1999
W J Cho M J Park T Imanishi B H Chung

Benzo[c]phenanthridine skeleton was synthesized from easily available starting N-methyl-o-toluamide 2 and o-methylbenzonitrile 5 in 7 steps. Radical cyclization of styrene 10 afforded 6,11-dimethyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one 13. Most 3-arylisoquinolines have displayed strong activities against human tumor cell lines. Especially, indenoisoquinolinone 13 exhibited excellent cy...

Journal: :Bioorganic & Medicinal Chemistry Letters 2021

Abstract Photodegradation of azilsartan produces a phenanthridine derivative, with its molecular structure determined by 1H and 13C NMR spectroscopy. This is confirmed single-crystal X-ray diffraction alternative synthesis. The ring formation explained through the closure an imidoylnitrene intermediate produced decarboxylation 5-oxo-1,2,4-oxadiazole (oxadiazolone).

Journal: :Chemical communications 2013
Cheng-Pao Cao Wei Lin Ming-Hua Hu Zhi-Bin Huang Da-Qing Shi

A series of new octahydrobenzo[b]indeno[1,2,3-de][1,8] naphthyridine and decahydropyrido[2,3,4-gh]phenanthridine derivatives were synthesized via a four-component domino reaction under microwave irradiation. This one-pot transformation, which involved multiple steps and did not require the use of a catalyst, constructed four new C-C bonds, two new C-N bonds, and three new rings, with efficient ...

2010
Min Zhang Xiang-Yang Wu Liu-Qing Yang

There are two independent mol-ecules in the asymmetric unit of the title compound, C(30)H(21)ClN(2)O, which differ slightly in the orientation of the unsubstituted phenyl ring. Inter-molecular C-H⋯π inter-actions stabilize the crystal structure. The crystal studied was found to be a racemic twin. The dihedral angles between the substituted phenyl ring and the benzo[c]phenanthridine system are 8...

Journal: :British Journal of Pharmacology and Chemotherapy 1954

Journal: :Acta Crystallographica Section E Structure Reports Online 2009

2014
Timothy C. Johnstone Stephen J. Lippard

The monofunctional platinum complex cis-[Pt(NH3)2Cl(Am)](+), also known as phenanthriplatin, where Am is the N-heterocyclic base phenanthridine, has promising anticancer activity. Unlike bifunctional compounds such as cisplatin, phenanthriplatin can form only one covalent bond to DNA. Another distinguishing feature is that phenanthriplatin is chiral. Rotation about the Pt-N bond of the phenanth...

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