The aim of this study is to propose a comprehensive approach for handling the crew scheduling problem in the railway systems. In this approach, the information of different railway trips are considered as input and the problem is divided to three separated phases. In phase I, we generate all feasible sequences of the trips, which are named as the pairings. A depth-first search algorithm is deve...

background : a wide range of preventive medications for migraine attacks, with varying efficacy is currently in use. studies comparing the efficacies of these drugs would be of value in the proper treatment of the disease. the present study compared the frequency, duration and intensity of migraine attacks during and following treatment with cyproheptadine (4 mg, twice daily) or blellergal (bel...

The migrating motor complex (MMC) shows large variations within an individual and between individuals. This study aimed to investigate, with respect to this variability, the importance of gastric or duodenal origin of phase III activity. Interdigestive 6- to 10-h stationary antroduodenal motility recordings of 19 healthy male subjects were analyzed for MMC cycle durations and duration of phases...

BACKGROUND Many more phase II studies have favorable outcomes than the subsequent phase III trials. We used historical data from phase II and phase III studies for patients with extensive-stage small-cell lung cancer (SCLC) to generate a statistical model to provide assistance in selecting chemotherapy regimens from phase II studies for subsequent use in phase III randomized studies. METHODS ...

BACKGROUND AND PURPOSE Most large, randomized phase III efficacy trials of therapeutic agents in ischemic stroke have failed to find treatment benefit. We determined whether some phase III studies could have been avoided if preceded by smaller single-arm phase II studies to evaluate the futility of proceeding to phase III. METHODS To provide examples of the application of phase II methodology...