The article studies whether training prior to laboratory work (with a multimedia interactive programme), as a complement to the traditional practicaltheoretical teaching of tablet manufacturing, has brought advantages to pharmaceutical technology learning and, in consequence, increased the quality of the tablets produced by the students in the educational pilot plant. Evaluation is a key aspect...

Multiple compressed tablets are compressed tablets made by more than one compression cycle. They are usually prepared to separate physically or chemically incompatible ingredients or to produce repeat or prolong action of drug. Compression coating perform similar functions as sugar or film coating except consists of dry coating concept hence prevents certain drawbacks of aqueous and non aqueous...

Direct tableting is simpler and more cost-effective from the point of view of good manufacturing practice (GMP) than wet granulation or dry compacting. Moreover, the use of dry plant extracts in the process of direct tableting, omitting granulation, decreases the possibility of biological activity loss of active substances. Thus, pharmaceutical industry uses this particular process more and mor...

This paper is on automated visual inspection of tablets that may, in contrast to manual tablet sorting, provide objective and reproducible tablet quality assurance. Visual inspection of the ever-increasing numbers of produced imprinted tablets, regulatory enforced for unambiguous identification of active ingredients and dosage strength of each tablet, is especially demanding. The problem become...

BACKGROUND/AIM Switching the patient from one pharmaceutical formulation of the same drug to another, may lead to therapeutic inadequancy in some cases. To minimize the risk, careful pharmacokinetic studies are desired in the pre-registration period and afterwards. METHODS A randomized, crossover design with one-week wash-out period between each dose was applied. Serum samples, obtained befor...

AIM OF THE STUDY Development of standardized, synergistic, safe and effective traditional herbal formulations with robust scientific evidence can offer faster and more economical alternatives for the treatment of disease. The main objective was to develop a method of preparation of guggulkalpa tablets so that the tablets meet the criteria of efficacy, stability, and safety. MATERIALS AND METH...

Strict measure on the need to control microbial contamination in the formulation of solid dosage forms such as tablets and capsules are not usually in place as is done in other pharmaceutical preparations. The presence of microorganisms in some common excipients such as starch and lactose powders, and distilled water used in tablet formulation was investigated in this study. Organisms isolated ...

The kinetic (or sliding) friction of pharmaceutical tablets and capsules influences how they will behave during the conveying, coating, and packaging operations that are used for drug product manufacturing. In order to logically design equipment for manufacturing and packaging operations, and to simulate manufacturing and packaging performance (for example, using discrete or finite element mode...

It is also useful in revealing the presence of impurities and structural disorder in materials, studying stress distributions, and temperature effects. Integration of Raman spectroscopy with Atomic Force Microscopy (AFM) opens a wide range of new capabilities in imaging and characterizing pharmaceutical products. For example, AFM topographic imaging provides information on the size of grains, t...

Optical coherence tomography (OCT) is a recently developed optical technique that produces depth profiles of three-dimensional objects. It is a nondestructive interferometric method responding to refractive index variation in the sample under study and can reach a penetration depth of a few millimetres. OCT employs near-infrared (NIR) light and therefore provides a link between NIR spectroscopy...