BACKGROUND Sex and gender sensitive inquiry is critical in pharmaceutical policy due to the sector's historical connection with women's health issues and due to the confluence of biological, social, political, and economic factors that shape the development, promotion, use, and effects of medicinal treatments. A growing number of research bodies internationally have issued laws, guidance or enc...

A rapid highly sensitive method to determine sample composition is reported. By monitoring the interaction between the sample of interest and a properly engineered nanopore, information regarding the identities and concentrations of the sample components could be revealed via their characteristic signatures, e.g., blockage amplitudes and event residence times. The sample composition method shou...

OBJECTIVES Many European countries regulate the markets for prescription drugs in order to cope with rising health expenditures. On the other hand, regulation distorts incentives to invest in pharmaceutical R&D. This study aims at empirically assessing the impact of regulation on pharmaceutical R&D expenditures. METHODS We analyze a sample of 20 leading pharmaceutical companies between 2000 a...

Abstract Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic,anti-infammatory and antipyretic actions. It is used to relieve mild to moderate pains. Solid-phase extraction of mefenamic acid by a polymer grafted to silica gel is reported . Poly allyl glycidyl ether/iminodiacetic acid-co-N, N-dimethylacrylamide was synthesized and grafted to silica gel and was used ...

OBJECTIVE To discuss factors related to the financing of the Basic Component of Pharmaceutical Services within the municipal management of the Brazilian Unified Health System. METHODS The Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil - Serviços (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services) is a ...

RNAExpressionMicroarray technology is widely applied in biomedical and pharmaceutical research. The huge number of RNA concentrations estimated for each sample make it difficult to apply traditional sample size calculation techniques and has left most practitioners to rely on rule-of-thumb techniques. In this paper, we describe and demonstrate a simple method for performing and visualizing samp...

mRNA Expression Microarray technology is widely applied in biomedical and pharmaceutical research. The huge number of mRNA concentrations estimated for each sample make it difficult to apply traditional sample size calculation techniques and has left most practitioners to rely on rule-of-thumb techniques. In this paper, we briefly describe and then demonstrate a simple method for performing and...

Automated sample preparation enables highly reproducible quantitative analyses while meeting the increased efficiency needs often required for sample processing in laboratories. This application note describes results obtained using a liquid handling-based automation system for the sample preparation of compounds to be analyzed by LC-MS/ MS and applied to the monitoring of multiple classes of p...

Traditional pharmaceutical analysis is focused almost exclusively on the end products of manufacturing processes. Samples are taken from drug substance or drug product batches and analyzed in a remote laboratory. The samples typically go through stages of documentation, sample preparation, analysis, data analysis and documentation once more, prior to the reporting of the analytical results. Thi...