نتایج جستجو برای: phage vaccine

تعداد نتایج: 127647  

2016
Maria Domina Veronica Lanza Cariccio Salvatore Benfatto Mario Venza Isabella Venza Danilo Donnarumma Erika Bartolini Erica Borgogni Marco Bruttini Laura Santini Angelina Midiri Roberta Galbo Letizia Romeo Francesco Patanè Carmelo Biondo Nathalie Norais Vega Masignani Giuseppe Teti Franco Felici Concetta Beninati

We explore here the potential of a newly described technology, which is named PROFILER and is based on next generation sequencing of gene-specific lambda phage-displayed libraries, to rapidly and accurately map monoclonal antibody (mAb) epitopes. For this purpose, we used a novel mAb (designated 31E10/E7) directed against Neisserial Heparin-Binding Antigen (NHBA), a component of the anti-group ...

Journal: :Journal of immunology 2002
Leslie J Matthews Robert Davis George P Smith

Antigenic peptides that bind pathogen-specific Abs are a potential source of subunit vaccine components. To be effective the peptides must be immunogenically fit: when used as immunogens they must elicit Abs that cross-react with native intact pathogen. In this study, antigenic peptides obtained from phage display libraries through epitope discovery were systematically examined for immunogenic ...

2017
Elham Omer Mahgoub

In this review, single-chain fragment variable construction using phage-display technology as a promising anticancer immunotherapy technology is described. Cloning and the specific bio-panning selection with phage display technology, as well as the use of the epidermal growth factor receptor (EGFR) at the surface of MCF-7 cells as the antigen for the straightforward specific selection of single...

2018
Hai Xu Xi Bao Yiwei Wang Yue Xu Bihua Deng Yu Lu Jibo Hou

BACKGROUND DNA delivery with bacteriophage by surface-displayed mammalian cell penetrating peptides has been reported. Although, various phages have been used to facilitate DNA transfer by surface displaying the protein transduction domain of human immunodeficiency virus type 1 Tat protein (Tat peptide), no similar study has been conducted using T7 phage. METHODS In this study, we engineeredT...

2016
Daniel Wibberg Anika Winkler Eberhard Straube Matthias Karrasch Peter M. Keller Jörn Kalinowski

Here, we present the draft genome sequence of ITALIC! Mycobacterium bovisBCG S4-Jena, a tuberculosis vaccine strain. The genome of S4-Jena is represented by 48 scaffolds, consisting of 132 scaffolded contigs and amounting to a size of about 4.2 Mb. New genes potentially encoding a phage fragment were identified in the genome.

Journal: :modares journal of medical sciences: pathobiology 2014
babak bakhshinejad mohammad khalaj-kondori saeedeh ghiasvand ghiasvand majid sadeghizadeh

objective: recently, phage display libraries have received enormous attention for identification and isolation of pharmaceutical molecules with diagnostic and therapeutic properties. peptide libraries are known as one of the most important and widely used types of phage display libraries. in the current study, we aimed to screen the ph.d.tm-7 phage display peptide library through biopanning for...

2011
Heath A. Smith Brett B. Maricque John Eberhardt Benjamin Petersen James L. Gulley Jeffrey Schlom Douglas G. McNeel

We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer. In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies. Sera were obtained from prosta...

Journal: :Bioengineering & Translational Medicine 2019

Journal: :Vaccine 2006
Guangwen Liu Meiying Yan Weili Liang Guoming Qi Yanqing Liu Shouyi Gao Biao Kan

The cholera toxin (CT) genes ctxAB are carried on a lysogenic phage of Vibrio cholerae, CTXPhi, which can transfer ctxAB between toxigenic and nontoxigenic strains of bacteria. This transfer may pose a problem when live oral cholera vaccine is given to people in epidemic areas, because the toxin genes can be reacquired by the vaccine strains. To address this problem, we have constructed a live ...

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