Efgartigimod (EFG) is an engineered Fc fragment that inhibits the activity of neonatal receptor (FcRn), thereby reducing levels circulating immunoglobulin G (IgG), including pathogenic IgG autoantibody, levels. EFG clinically efficacious and generally well tolerated in phase 2 3 trials multiple IgG-mediated disorders. Bullous pemphigoid (BP) autoimmune blistering disease, characterized by subep...

Substantial evidence supports a role for chronic subclinical inflammation in the pathogenesis of insulin resistance (1,2). The inflammation induces a number of local and systemic responses, including extracellular matrix (ECM) remodeling. ECM is normally one of the most important regulators of cellular and tissue function in the body since it acts as a scaffold for cell migration, a reservoir f...

Vasectomy is a simple and reliable method of male contraception. A growing number of men after vasectomy request vasectomy reversal due to various reasons. The pregnancy rate is lower than the patency rate after vasovasostomy and the pregnancy rate is time dependent. In this study, we evaluated the influence of reproductive tract obstruction on expression of epididymal proteins and their restor...

Hyaluronan (HA) has many functions in the extracellular milieu of normal and diseased tissues. Disease-associated HA accumulation has been shown to predict a worsened prognosis in cancer patients, with tumors having a high-extracellular HA content (HA-high) being more aggressive than their HA-low counterparts. HA-high tumor aggressiveness is derived from the specialized biomechanical and molecu...

Despite tremendous progress in cancer immunotherapy for solid tumors, clinical success of monoclonal antibody (mAb) therapy is often limited by poorly understood mechanisms associated with the tumor microenvironment (TME). Accumulation of hyaluronan (HA), a major component of the TME, occurs in many solid tumor types, and is associated with poor prognosis and treatment resistance in multiple ma...

OBJECTIVE To compare the pharmacokinetics, pharmacodynamics, and safety of insulin lispro or regular human insulin (RHI) with or without recombinant human hyaluronidase (rHuPH20) administered before a standardized meal. RESEARCH DESIGN AND METHODS In this four-way, crossover study, 22 patients with type 1 diabetes received injections of individually optimized doses of lispro or RHI with and w...