The fundamental biophysics underlying the selective movement of ions through ion channels was launched by George Eisenman in the 1960s, using glass electrodes. This minireview examines the insights from these early studies and the explosive progress made since then.

The differentiation of resting B lymphocytes to Ig secretion involves several sequential steps regulated by antigen, T lymphocytes, and macrophages. The requirement for T cells may in some cases be replaced by lymphokines secreted upon T cell activation (1, 2). A number of distinct T cell-derived lymphokines have been described (3-9) that directly regulate the growth and maturation of B cells. ...

THF-gramicidin hybrids 2-4 with the L-THF amino acid 1 in positions 11 and 12 and compounds 5-8 with the D-THF amino acid ent-1 in positions 10 and 11 were synthesized and their ion channel properties were studied by single-channel-current analysis. The replacement of positions 11 and 12 by the L-THF amino acid 1 gave a strongly reduced channel performance. In contrast, replacement of positions...

In the introduction to the recent JGP series Perspectives on: Ion selectivity, Andersen (2011) notes that present theoretical models do not yet deal fully with the energetic consequences of the known flexibility of ion binding sites in proteins (how changes in flexibility alter the ion selectivity of a site). I therefore write to point out that this question was addressed long ago by Eisenman a...

It is difficult to estimate the efficacy of the various treatments and impact of prognostic factors for ISSHL because the natural history of ISSHL is still unknown (Fetterman et al., 1996). There have been many studies reported the effect of various treatment including systemic corticosteroids, tympanic corticosteroids injection, antiviral, anticoagulant, and vitamin etc. on ISSHL, but the resu...

10.1128/MCB.23.20.7222-7229.2003. 2003, 23(20):7222. DOI: Mol. Cell. Biol. Kahn and Bruce M. Spiegelman Eisenman, Mark A. Magnuson, Frank J. Gonzalez, C. Ronald Ozcan, Terumasa Okada, Chung-Hsin Hsu, Daniel Evan D. Rosen, Rohit N. Kulkarni, Pasha Sarraf, Umut Homeostasis without Compromising Glucose Leads to Abnormalities in Islet Mass Cells β in γ Proliferator-Activated Receptor Targeted Elimi...

Transepithelial secretion in Malpighian tubules of the yellow fever mosquito (Aedes aegypti) is mediated by active transport of Na(+) and K(+) through principal cells and passive Cl(-) transport through the shunt. Permeation through the shunt was assessed by measuring transepithelial halide diffusion potentials in isolated perfused Malpighian tubules, after first inhibiting active transport wit...