background: despite the relative success of surgical resection followed by proton, proton/photon, or conventional radiotherapy in terms of recurrence-free survival, chordomas are still associated with a high rate of recurrence. to our knowledge there are only very few reported cases of this rare tumor detected by f-18 fdg-pet. materials and methods: in this case we show the significance of f-18...

Background: Despite the relative success of surgical resection followed by proton, proton/photon, or conventional radiotherapy in terms of recurrence-free survival, chordomas are still associated with a high rate of recurrence. To our knowledge there are only very few reported cases of this rare tumor detected by F-18 FDG-PET. Materials and Methods: In this case we show the significanc...

Molecular imaging with PET is a rapidly emerging technique. In breast cancer patients, more than 45 different PET tracers have been or are presently being tested. With a good rationale, after development of the tracer and proven feasibility, it is of interest to evaluate whether there is a potential meaningful role for the tracer in the clinical setting-such as in staging, in the (early) predic...

UNLABELLED Conventional myocardial perfusion PET tracers require onsite tracer production because of their short radioactive half-lives. To investigate the potential of a new (18)F-labeled pyridazinone analog ((18)F-BMS-747158-02), we characterized this tracer in a rat model of permanent and transient coronary occlusion using small-animal PET. METHODS Myocardial (18)F-BMS-747158-02 distributi...

PURPOSE [(18)F]FLT (3'-Fluoro-3' deoxythymidine)-PET imaging was proposed as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate the use of [(18)F]FLT-PET imaging for measuring xenograft proliferation and subsequent monitoring of targeted therapy. EXPERIMENTAL DESIGN In exponentially growing xenografts, factors that could impact the outcome of [(18)F...

UNLABELLED Clinical PET of apoptosis may have substantial value in advancing patient care. We report here the first-in-humans study with (18)F-labeled 2-(5-fluoropentyl)-2-methyl malonic acid ((18)F-ML-10), a small-molecule PET tracer for apoptosis. Presented are the dosimetry, biodistribution, stability, and safety profiles of this PET tracer in healthy human volunteers. Also reported is trace...

The application of microfluidics to the synthesis of Positron Emission Tomography (PET) tracers has been explored for more than a decade. Microfluidic benefits such as superior temperature control have been successfully applied to PET tracer synthesis. However, the design of a compact microfluidic platform capable of executing a complete PET tracer synthesis workflow while maintaining prospects...

We present the case of a 60-year-old man with metastatic neuroendocrine tumor of the ileum following ileal resection, being evaluated for 177Lu-based peptide receptor radionuclide therapy. 68Ga-DOTANOC PET/CT showed focal increased tracer uptake in the scrotal region without any morphologic changes on the corresponding CT images. Similar increased tracer uptake was seen on...

Molecular imaging using PET provides a unique tool for noninvasively investigating the biochemistry of living organs. The wide range of radiolabeled molecules makes it possible to explore various biochemical, physiologic, and pharmacologic processes in vivo. Because each radiotracer is characterized by its particular kinetic behavior in the human body, the quantification of this behavior is a c...

PET and SPECT using appropriate radioligands allow imaging of certain critical components of neurotransmission such as presynaptic transporters and postsynaptic receptors in living human brains. PET and SPECT data are commonly analyzed by applying tracer kinetic models. These modeling approaches assume a compartmental system and derive the outcome measure called the binding potential, which ref...