Metastasis is a multistep molecular network process, which is the major cause of death in patients with colorectal cancer (CRC). MicroRNAs (miRNAs) play pivotal roles in tumorigenesis as either tumor suppressors or oncogenes. Increased expression of fucosyltransferase4 (FUT4) has been reported to be associated with the invasive and metastatic properties of CRC. Here to identify potential key mi...

Purpose: To investigate the effects of miR-34a and miR-26b on targeted genes, LEF1 EphA2, proliferation apoptosis OPCN-1.Methods: Sixty specimens cancer tissue (CT) equivalent adjacent to tumors (TAT) were collected from prostate patients. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used determine mRNA expression levels miR-34a, miR-26b, LEF1, EphA2 in above tissu...

AIMS GATA4 is a transcription factor that is up-regulated during cardiac hypertrophy and plays a fundamental role in myocyte growth and survival. In this study, we investigate the transcriptional vs. post-transcriptional mechanisms that are involved in regulating GATA4 in the heart during neonatal and pressure overload-induced hypertrophic growth. METHODS AND RESULTS GATA4 protein is signific...

Infectious Pancreatic Necrosis Virus (IPNV) is a member of the family Birnaviridae that has been linked to high mortalities in salmonids. Bacterial based systems as live vectors for the delivery of heterologous antigens offer a number of advantages as vaccination strategies. VP2 is a structural viral protein of IPNV with immunogenicity effects. In this study IPNV was isolated from diseased fry ...

Ketil Haugan M.D. a, Anne Louise Kjølbye Ph.D. a, James K. Hennan, Ph.D. b, and Jørgen Søberg Petersen M.D., Ph.D., D.Sc. a , Zealand Pharma A/S, Smedeland 26B, DK-2600 Glostrup, Denmark. , Wyeth Research, Philadelphia, PA, USA * Correspondance and request for reprints: Ketil Haugan, Zealand Pharma A/S, Smedeland 26B, DK-2600 Glostrup, Denmark. Fax: +45 43281212. Phone: +45 43281263. E-mail: kh...

Osteoarthritis (OA) is a common chronic joint disease, the etiology of which is complex. Disturbance to proinflammatory and anti‑inflammatory signaling pathways is a major cause of OA. MicroRNAs (miRNAs/miR) are a group of endogenous, short, non‑coding RNAs, the expression profile of which is disturbed in the cartilage of patients with OA. To determine the function of miRNAs during the progress...

MicroRNAs are involved in the control of cell growth, and deregulated pulmonary artery smooth muscle cell proliferation plays an essential role in the development of pulmonary hypertension. The objective of this study was to identify differentially expressed microRNA(s) and explore its therapeutic role in treatment of the disease. MicroRNA expression profile analysis showed microRNA-26b was dif...

Abstract Background Pericoronary adipose tissue (PCAT) plays a key role in the pathogenesis of atherosclerosis. PCAT is source microRNAs (miRs) that acts as messengers for intercellular communication. In this study, we investigated whether surrounding coronary occlusive atherosclerotic lesions shows specific miR expression patterns compared to plaque-free segments. Purpose To evaluate miRs are ...

Objective(s): Although low-dose radiotherapy (RT) that involves low collateral damage is more suitable for hepatocellular carcinoma (HCC) than traditional high-dose RT, but to achieve satisfactory therapeutic effect with low-dose RT, it is necessary to sensitize HCC cells to irradiation. This study was aimed to determine whether radiosensitivity of HCC cells can be enhanced using miR-26b by tar...