background: leishmania, needs to detoxify the macrophage derived potent peroxides (h2o2). tryparedoxin path­way contains tryparedoxin peroxidase (tsa or tryp). the aim of the study was to detect the full-length gene se­quence and its encoded protein of the lmtryp6 gene (eu251502), and comparison the gene sequence with lmtryp6 (lmjf15.1140), another previously reported member of this gene family...

Background: Culture media enrichment through the addition of protein hydrolysates is beneficial for achieving higher protein expression. Methods: In this study, designing the optimum mixture of four soy and casein-derived hydrolysates was successfully performed by design of experiment and specific productivity increased in all predicted combinations. Protein profile of recombinant CHO (rCHO) ce...

Peroxiredoxin 4 (Prx4) is the only endoplasmic reticulum localized peroxiredoxin. It functions not only to eliminate peroxide but also to promote oxidative protein folding via oxidizing protein disulfide isomerase (PDI). In Prx4-mediated oxidative protein folding we discovered a new reaction that the sulfenic acid form of Prx4 can directly react with thiols in folding substrates, resulting in n...

This study’s objective was to determine the impact of a dual respiratory and enteric bacterial health challenge on antioxidant protein peroxiredoxin-2 (Prdx-2) profile oxidation in skeletal muscle pigs from 2 lines that were divergently selected for residual feed intake (RFI). The hypotheses (1) differences exist Prdx-2 between RFI infection status (2) less efficient high-RFI health-challenged ...

Eukaryotic peroxiredoxins are highly susceptible to sulfinic acid formation. This overoxidation, which is thought to convert peroxiredoxins into chaperones, can be reversed by sulfiredoxins. Several organisms, including Caenorhabditis elegans, lack sulfiredoxins but encode sestrins, proteins proposed to be functionally equivalent. We induced peroxiredoxin overoxidation in C. elegans with a shor...

Four distinct proteins are regulated in the aging neuroretina and may be regulated in the cerebral cortex, too: peroxiredoxin, beta-synuclein, PARK[Parkinson disease(autosomal recessive, early onset)]7/DJ-1, and Stathmin. Thus, we performed a comparative analysis of these proteins in the the primary somatosensory cortex (S1) and primary visual cortex (V1) in rats, in order to detect putative co...