pidemic drug clofibrate (ethyl-a-p-chlorophenoxyisobutyr ate) in lowering serum lipid levels in experimental animals (49) but it did not enter into clinical trials, possibly due to suspected hepatotoxicity in experimental animals. Previous work by Reddy and Knishnakantha (31) showed that Wy 14,643 caused a significant hepatomegaly and produced a marked increase in the hepatic peroxisome populat...

They thus provide a plausible link between the induction of physiological PPAR␥ targets and systemic insulin sensitization (Spiegelman and Flier, 1996). Summary PPARs belong to a subclass of nuclear hormone receptors that, like the retinoic acid, vitamin D, and thyroid The nuclear hormone receptor PPAR␥ promotes adi-pogenesis and macrophage differentiation and is a hormone receptors, execute th...

pidemic drug clofibrate (ethyl-a-p-chlorophenoxyisobutyr ate) in lowering serum lipid levels in experimental animals (49) but it did not enter into clinical trials, possibly due to suspected hepatotoxicity in experimental animals. Previous work by Reddy and Knishnakantha (31) showed that Wy 14,643 caused a significant hepatomegaly and produced a marked increase in the hepatic peroxisome populat...

an organism are compared. In mammals, for example, the ER is vastly abundant in exocrine pancreatic secre-where there is no appreciable demand for the secretion of any protein (Bolender, 1974). Using representative examples primarily from the yeast Saccharomyces cere-One hallmark of eukaryotic cells is that they contain visiae, we highlight in this review some recent insights many functionally ...

Walking a fine caspase line W hether caspase enzymes perform developmental tasks or cause cell death can depend on the timing with which a caspase inhibitor protein turns over, fi nd Koto et al. They show that the inhibitor protein follows a dramatic temporal regulation specifi c to cell type and maturity. In the last decade, researchers realized that the destructive capabilities of caspase enz...

This paper reviews the application of indirect electro-oxidation processes such as electroFenton, photoelectro-Fenton and peroxi-coagulation to decontaminate waters containing persistent pesticides. The fundamentals of these electrochemical advanced oxidation processes (EAOPs) are described. They are environmentally friendly technologies based on the electrogeneration of H2O2 at a carbonaceous ...

The w-oxidation of fatty acids results in the formation of mediumand long-chain dicarboxylates. By this accessory metabolic pathway monocarboxylic acids are first converted into w-hydroxymonocarboxylic acids, a reaction catalysed by the microsomal mixed-oxidase function system (Pettersen, 1972). These intermediates are subsequently converted into w-oxomonocarboxylic acids and dicarboxylic acids...

several laundry houses throughout tehran consume a large amount of water each day and discharge the resulting wastewater into septic tanks or municipal sewage system without any suitable pretreatment. this would result in severe contamination and other serious environmental issues. in the present study, performance of electrocoagulation/flotation process with aluminum and iron electrodes is com...

Benign smooth muscle tumors of the female urethra are rare. A case of urethral leiomyoma which had been present for 18 years before surgical removal is reported. The pathogenesis and the clinical aspects of this unusual clinical condition are discussed. Prof. Cesare Selli, Clinica Urologica, Viale Pieraccini 18, I-50139 Florence (Italy) Introduction Leiomyomas of the female genital tract are co...