With the rise in antibiotic resistance amongst pathogenic bacteria, the study of antibiotic activity and transport across cell membranes is gaining widespread importance. We present a novel, label-free microfluidic assay that quantifies the permeability coefficient of a broad spectrum fluoroquinolone antibiotic, norfloxacin, across lipid membranes using the UV autofluorescence of the drug. We u...

reservoir permeability is a critical parameter for characterization of the hydrocarbon reservoirs. in fact, determination of permeability is a crucial task in reserve estimation, production and development. traditional methods for permeability prediction are well log and core data analysis which are very expensive and time-consuming. well log data is an alternative approach for prediction of pe...

Abstract: Minoxidil, a pyrimidine derivative (2, 4-diamino-6-piperidinopyrimidine-3-oxide) is the only topical medical treatment with proven efficacy for the treatment of Androgenetic alopecia that shown low skin penetration and bioavailability. The main aim of this research was to investigate the effect of some permeation enhancers on the in vitro skin permeability of minoxidil . Minoxid...

sorption of flavor compounds to inner layer of polymer packages and subsequent diffusion results in loss of food flavor and consequently decreases shelf life and consumer acceptance of food stuffs which in turn causes major economic losses, so it is of utmost importance to research on diffusivity of these compounds in polymers to minimize negative effects of this phenomenon. in current research...

Nystatin and amphotericin B increase the permeability of thin (<100 A) lipid membranes to ions, water, and nonelectrolytes. Water and nonelectrolyte permeability increase linearly with membrane conductance (i.e., ion permeability). In the unmodified membrane, the osmotic permeability coefficient, P(f), is equal to the tagged water permeability coefficient, (P(d))(w); in the nystatin- or amphote...

in this research, the bioinsising impact of two wood decay fungi (pysisporinus vitreus and xylaria longipes) on radial air permeability and moisture diffusion coefficient of spruce wood (picea abies) was investigated. fungal cultivation was performed in an incubator at 25 °c and 85% relative humidity for 15, 30 and 45 days. results showed that the permeability, moisture diffusion and mass loss ...

The comparative in vitro skin permeability of diclofenac sodium through excised mouse skin from different common pharmaceutical vehicles like castor oil, olive oil, arachis oil, liquid paraffin, white soft paraffin melt, 3% sodium carboxymethyl cellulose (CMC) aqueous gel and isopropyl myristate (IPM), excluding other excipients was evaluated. Significantly (p < 0.05) higher flux of diclofenac ...

Water permeability coefficients of dog, cat, and beef red cell membranes have been measured under an osmotic pressure gradient. The measurements employed a rapid reaction stop flow apparatus with which cell shrinking was measured under a relative osmotic pressure gradient of 1.25 to 1.64 times the isosmolar concentration. For the dog red cell the osmotic permeability coefficient is 0.36 cm(4)/(...