We evaluate whether the tumor immune infiltrate (TIL) could be used for prediction of responsiveness to preoperative chemoradiotherapy (PCRT) in rectal cancers. Using formalin-fixed paraffin-embedded slides of pretreatment biopsies, co-stain for CD4, CD8, CD274 (PD-L1), FOXP3, cytokeratin, and DAPI was performed with Opal multi staining kit (Perkin-Elmer, Waltham, MA). Multispectral imaging and...

The well being of modern society is unimaginable without the myriad products of industrial organic synthesis. Our quality of life is strongly dependent on, inter alia , the products of the pharmaceutical industry, such as antibiotics for combating disease and analgesics or anti infl ammatory drugs for relieving pain. The origins of this industry date back to 1935, when Domagk discovered the ant...

Summary Background Porcelain gallbladder (PGB) is defined as calcium deposits encrusting the internal visceral layer, which becomes hard, brittle, and bluish. rare has been found in less than 1% of routine cholecystectomy specimens. Several studies report an incidence carcinoma (GBC) associated with calcification varying between 12.5 61%, data have known for 60 years. There a lack information c...

5. Ernster. I,.. Dallner, G. and Azzone, G. F. (1963) J. Hiol. Chem. 238, 1 124 6. Johnson-Flanagan, A. M. and Spencer, M. S. (1981) Plant Physiol. 68, 12 1 1 7. Carson. D., Cass, M. W., Crombie, L., Holden, I. and Whiting, I). A. (1982) J. Chem. SOC. Perkin Trans. 1, 773 (and references cited therein) 8. h i , S. M. F., Orchison, J. J. A. and Whiting, D. A. (1989) Tetrahedron b, 5895 9. Ise, W...

The viscoelastic properties of three commercially available resin-based composites (FiltekTM P60, FiltekTM Supreme, and FiltekTM Z250; 3M ESPE, Bracknell, UK) were measured to determine the effect of beverages on their storage moduli and damping ratios. Rectangular samples of the three hybrid composites were immersed in three beverages at 37 °C for 1, 7, 30, and 60 days. At each time interval, ...

Twofold Perkin condensation of 2,5-dibromophenylene-1,4-diacetic acid with arylglyoxylic acids followed by cyclo-dehydrobromination leads to dipyreno- and diperyleno-anthracene tetraesters and diimides. The imides show surprisingly large absorption shifts versus the esters, illustrating that electron-withdrawing substituents at the anthracene unit efficiently impart long wavelength absorption i...