background: t-2 toxin is a mycotoxin of type a trichothecenes produced by several fungal genera such as fusarium species. mycotoxins can affect both cell mediated and humoral immune compartments. objective: the purpose of this study was to investi-gate the effect of t-2 toxin on cytokine production by mouse peritoneal macrophages and lymph node t cells. methods: mouse peritoneal macrophages and...

Introduction: Based on human studies, inequality and social injustice have adverse effects on the individual and community health. In this study, the effects of food intake inequality and social status changes on pain perception and immunological factors were investigated in Balb/C mice. Methods: The present study was conducted by implementing different social stresses including food depriva...

Background: Macrophages activation is the important anti-leishmania immune response. Different signals could affect macrophages development and functional activation. Objectives: In the present study, we compared the effect of Leishmania Soluble Antigen (LSA)and Lipopolysaccharide (LPS) on peritoneal macrophage responses. Appropriate activation of macrophages depends on thesignals they receive ...

The aim of this study was to clarify the phagocytic mechanisms of a heat-killed cell preparation of Enterococcus faecalis strain EC-12 (EC-12) by antigen-presenting cells (APCs). Fluorescein isothiocyanate (FITC)-labeled EC-12 was cocultured with peritoneal macrophage and the amount of EC-12 phagocytosed by peritoneal macrophages was measured using a microplate fluorometer. Peritoneal macrophag...

The transcription factor Gata6 regulates proliferation and differentiation of epithelial and endocrine cells and cancers. Among hematopoietic cells, Gata6 is expressed selectively in resident peritoneal macrophages. We thus examined whether the loss of Gata6 in the macrophage compartment affected peritoneal macrophages, using Lyz2-Cre x Gata6(flox/flox) mice to tackle this issue. In Lyz2-Cre x ...

STK, a new member of the hepatocyte growth factor receptor family, is the receptor for macrophage-stimulating protein (MSP), which acts on murine resident peritoneal macrophages. We established polyclonal and monoclonal antibodies against STK and characterized the structure of STK protein and STK expression on cells of the mononuclear phagocyte system. Western blotting showed that the STK trans...

Macrophages are often conspicuous in asbestos-induced inflammatory lesions. Chrysotile type B elicits macrophages into the peritoneal cavity of mice which produce high levels of the neutral protease, plasminogen activator; in vitro addition of these same fibers to mouse peritoneal macrophages stimulates enzyme production. It is reported here that, for endotoxin-elicited mouse peritoneal macroph...

in a preliminary experiment. the protective effects of ' peritoneal macrophages was shown by transferring macroph. ages fr-om adult mice to newborn and to 7 and 14 days old mice. it suckling mice from intraperitoneal infection with mcmv by reducing the mortality rate from 100% to 27%.was demontrated that such transplentatton protect

The p38 mitogen-activated protein kinase (MAPK) plays a key role in lipopolysaccharide (LPS)-induced signal transduction pathways that lead to inflammatory cytokine synthesis in macrophages; however, whether the inhibition of p38 MAPK regulates LPS-induced inflammatory cytokine expression in different types of macrophages remains the subject of debate. Herein, we assessed whether the inhibition...

Patients undergoing CAPD are prone to episodes of peritonitis caused principally by infection with Staphylococcus epidermidis. Since macrophages are believed to be of prime importance in protection of the peritoneal cavity we have examined certain activities of CAPD peritoneal macrophages and compared them with normal peritoneal macrophages and blood monocytes. CAPD macrophages were obtained fr...