The peritoneal surface remains an important failure site for patients with gastrointestinal and gynecologic malignancies. In the past, oncologists regarded peritoneal carcinomatosis as an incurable component of an intra-abdominal malignancy. During the last two decades, novel therapeutic approaches have emerged for peritoneal carcinomatosis patients. We report the first case of peritoneal carci...

Peritoneal carcinomatosis results from dissemination of solid tumors in the peritoneal cavity, and is a common site of metastasis in patients with carcinomas of gastrointestinal or gynecological origin. Peritoneal carcinomatosis treatment is challenging as poorly vascularized, disseminated peritoneal micro-tumors are shielded from systemic anticancer drugs and drive tumor regrowth. Here, we des...

HYPOTHESIS The most common cause of palliative resection and recurrence in gastric cancer is peritoneal seeding. This study evaluates the efficacy of intraperitoneal chemohyperthermia after cytoreductive surgery in patients with peritoneal carcinomatosis arising from gastric cancer. DESIGN Prospective clinical trial. SETTING Surgical department at a university academic hospital. PATIENTS ...

Peritoneal carcinomatosis is a well-known factor of poor prognosis in patients with digestive adenocarcinomas. Peritoneal dissemination may also occur in midgut well-differentiated neuroendocrine tumors, but its influence on survival is ill-defined. We report here the history of a 64-year-old woman who had a neuroendocrine tumor of the cecum with multiple synchronous metastases in the liver and...

BACKGROUND 15% to 20% of patients with metastatic colorectal cancer show isolated peritoneal carcinomatosis with significat clinical relevance. Their prognosis is poor, with a reported mean survival of less than one year. Moreover, there is a lack of knowledge regarding treatment optimally tailored to individual patients. METHODS To identify and characterize the current treatment options for ...

A 67-year-old male presented with fatigue, abdominal pain , and 30-pound weight loss over 3 months. Computerized tomography (CT) abdomen displayed ascites with thickening and enhancement of the peritoneum and mottled nodular appearing as soft tissue consistent with omental caking worrisome for peritoneal carcinomatosis. A paracentesis revealed white blood cell count of 2,500 with 98% lymphocyte...

CONTEXT Patients with peritoneal carcinomatosis have a dismal prognosis despite systemic chemotherapy or palliative surgery. A novel strategy of complete tumor debulking with intraoperative hyperthermia with chemotherapy has been proposed to provide prolonged survival. OBJECTIVE To retrospectively analyze the preliminary experience with this technique at Baylor University Medical Center. ME...

BACKGROUND The best method to deliver intraperitoneal chemotherapy (IPC) for peritoneal carcinomatosis from ovarian cancer is not well defined. The aim of this study was to assess the ability of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a rat model of peritoneal carcinomatosis. METHODS Four groups of 5 BDIX rats with ovarian peritoneal carcinomatosis...

INTRODUCTION Peritoneal carcinomatosis is a frequent form of disease progression in gastrointestinal cancer, and all too often is a preterminal event with a median survival of only 6 months. Despite the introduction of aggressive surgical and chemotherapeutic approaches, any significant improvement in survival is unlikely until we better understand the molecular biology of peritoneal metastasis...