نتایج جستجو برای: per1

تعداد نتایج: 620  

Journal: :Neuroscience 2008
M Angeles-Castellanos R Salgado-Delgado K Rodríguez R M Buijs C Escobar

The clock gene protein Per 1 (PER1) is expressed in several brain structures and oscillates associated with the suprachiasmatic nucleus (SCN). Restricted feeding schedules (RFS) induce anticipatory activity and impose daily oscillations of c-Fos and clock proteins in brain structures. Daily access to a palatable treat (chocolate) also elicits anticipatory activity and induces c-Fos expression m...

Journal: :The European respiratory journal 2008
N Burioka S Koyanagi M Endo M Takata Y Fukuoka M Miyata K Takeda H Chikumi S Ohdo E Shimizu

Clock genes regulate mammalian circadian rhythms, and dysfunction of clock genes can contribute to various disorders. To investigate whether obstructive sleep apnoea syndrome (OSAS) influences clock gene function, the present authors examined Period1 (Per1) mRNA expression in vitro and in vivo. In eight healthy subjects and eight OSAS patients, plasma noradrenaline, serum interleukin (IL)-6, hi...

Journal: :Molecular and cellular neurosciences 2008
Céline A Feillet Jorge Mendoza Urs Albrecht Paul Pévet Etienne Challet

Clock proteins like PER1 and PER2 are expressed in the brain, but little is known about their functionality outside the main suprachiasmatic clock. Here we show that PER1 and PER2 were neither uniformly present nor identically phased in forebrain structures of mice fed ad libitum. Altered expression of the clock gene Cry1 was observed in respective Per1 or Per2 mutants. In response to hypocalor...

2017
Nathaniel Hassan Kirstin McCarville Kenzo Morinaga Cristiane M Mengatto Peter Langfelder Akishige Hokugo Yu Tahara Christopher S Colwell Ichiro Nishimura

Circadian rhythms maintain a high level of homeostasis through internal feed-forward and -backward regulation by core molecules. In this study, we report the highly unusual peripheral circadian rhythm of bone marrow mesenchymal stromal cells (BMSCs) induced by titanium-based biomaterials with complex surface modifications (Ti biomaterial) commonly used for dental and orthopedic implants. When c...

Journal: :Cancer research 2007
Walter Krugluger Anita Brandstaetter Enikö Kállay Johann Schueller Elisabeth Krexner Stefan Kriwanek Elisabeth Bonner Heide S Cross

Expression of dihydropyrimidine dehydrogenase (DPD) displays a regular daily oscillation in nonmalignant cells. In colorectal cancer cells, the expression of this 5-fluorouracil-metabolizing enzyme is decreased, but the reason remains unclear. In this study, we analyzed by real-time reverse transcription-PCR (RT-PCR) the expression of DPD and of members of the cellular oscillation machinery, pe...

Journal: :Neoplasia 2007
Sherry L Winter Lucine Bosnoyan-Collins Dushanthi Pinnaduwage Irene L Andrulis

There is a growing body of evidence implicating aberrant circadian clock expression in the development of cancer. Based on our initial experiments identifying a putative interaction between BRCA1 and the clock proteins Per1 and Per2, as well as the reported involvement of the circadian clock in the development of cancer, we have performed an expression analysis of the circadian clock genes Per1...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Sandra J Kuhlman Rae Silver Joseph Le Sauter Abel Bult-Ito Douglas G McMahon

The endogenous circadian clock of the mammalian suprachiasmatic nucleus (SCN) can be reset by light to synchronize the biological clock of the brain with the external environment. This process involves induction of immediate-early genes such as the circadian clock gene Period1 (Per1) and results in a stable shift in the timing of behavioral and physiological rhythms on subsequent days. The mech...

Journal: :Molecular pharmacology 2007
Xiaoyu Qu Richard P Metz Weston W Porter Vincent M Cassone David J Earnest

The biological effects of many environmental toxins are mediated by genes containing Per-Arnt-Sim (PAS) domains, the aryl hydrocarbon receptor (AhR), and AhR nuclear translocator. Because these transcription factors interact with other PAS genes that form the circadian clockworks in mammals, we determined whether targeted disruption of the clock genes, Per1 and/or Per2, alters toxin-induced exp...

2011
Jing Zhang Zhouqiao Wu Linglin Zhou Huili Li Huajing Teng Wei Dai Yongqing Wang Zhong Sheng Sun

Acute stressors induce changes in numerous behavioral parameters through activation of the hypothalamic-pituitary-adrenal (HPA) axis. Several important hormones in paraventricular nucleus of the hypothalamus (PVN) play the roles in these stress-induced reactions. Corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP) and corticosterone are considered as molecular markers for stress-i...

Journal: :Developmental cell 2006
Jacqueline A Walisser Christopher A Bradfield

A variety of molecular, genomic and epidemiological evidence has linked cell cycle regulation to circadian rhythms. In a recent issue of Molecular Cell, Koeffler and colleagues show that PER1 sensitizes human cancer cells to ionizing radiation-induced apoptosis. In addition, PER1 expression was found to be downregulated in human tumors, suggesting a tumor suppressor role for the PER1 protein. T...

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