نتایج جستجو برای: penk

تعداد نتایج: 312  

Journal: :Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2008
B Wylot J Staszkiewicz S Okrasa

In previous studies the effect of endogenous opioid peptides (EOP) on LH secretion was mainly considered at the hypothalamic level, while opioid involvement in the modulation of LH secretion at the pituitary level remains insufficiently elucidated. Therefore, the present study was undertaken to determine the expression of genes encoding opioid precursors--proopiomelanocortin (POMC), proenkephal...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011
Woonbok Chung Jolanta Bondaruk Jaroslav Jelinek Yair Lotan Shoudan Liang Bogdan Czerniak Jean-Pierre J Issa

BACKGROUND Bladder cancer (BCa) remains a lethal malignancy that can be cured if detected early. DNA hypermethylation is a common epigenetic abnormality in cancer that may serve as a marker of disease activity. METHODS We selected 10 novel candidate genes from the most frequently hypermethylated genes detected by DNA microarray and bisulfite pyrosequencing of bladder cancers and applied them ...

Journal: :Addiction biology 2009
Emilie Belkaï Jean-Michel Scherrmann Florence Noble Cynthia Marie-Claire

The delta opioid system is involved in the behavioral effects of various drugs of abuse. However, only a few studies have focused on the possible interactions between the opioid system and the effects of 3,4-methylenedioxymethamphetamine (MDMA). In order to examine the possible role of the delta opioid system in MDMA-induced behaviors in mice, locomotor activity and conditioned place preference...

Journal: :The Journal of clinical investigation 2013
Michael Michaelides Sarah Ann R Anderson Mala Ananth Denis Smirnov Panayotis K Thanos John F Neumaier Gene-Jack Wang Nora D Volkow Yasmin L Hurd

The ability to map the functional connectivity of discrete cell types in the intact mammalian brain during behavior is crucial for advancing our understanding of brain function in normal and disease states. We combined designer receptor exclusively activated by designer drug (DREADD) technology and behavioral imaging with μPET and [18F]fluorodeoxyglucose (FDG) to generate whole-brain metabolic ...

2015
Jean-Pierre Roperch Karim Benzekri Hicham Mansour Roberto Incitti

BACKGROUND Using quantitative methylation-specific PCR (QM-MSP) is a promising method for colorectal cancer (CRC) diagnosis from stool samples. Difficulty in eliminating PCR inhibitors of this body fluid has been extensively reported. Here, spermidine is presented as PCR facilitator for the detection of stool DNA methylation biomarkers using QM-MSP. We examined its effectiveness with NPY, PENK ...

2012
Xinxin Yang Yinghui Chen Xiaoyun Hong Na Wu Lu Song Weien Yuan Zhenguo Liu

BACKGROUND Levodopa is the gold standard in the treatment of Parkinson's disease (PD). However, long-term levodopa replacement therapy is accompanied by abnormal involuntary movements (AIMs), known as levodopa-induced dyskinesia (LID). Until now, the precise mechanisms of LID were only partially understood. Previous studies have shown that continuous dopamine stimulation was helpful in reducing...

2015
Yuan Lu Nicholas Starkey Wei Lei Jilong Li Jianlin Cheng William R. Folk Dennis B. Lubahn Rajeev Samant

Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cell...

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