Steadily increasing interest in penicillin as a chemotherapeutic agent has led to a parallel increase in the demand for penicillin for clinical application and chemical studies. Penicillin is produced in minute quantities by Penicillium notatum so that filtrates from the mold represent exceedingly dilute solutions of penicillin from which the active agent is extracted. The magnitude of the prob...

In our screening of microorganisms for new natural products, the fungus Penicillium notatum delivered further members of the sorbicillin family, namely, the sohirnones A [3, 1-(2,4-dihydroxy-5-methylphenyl)hex-4-en-1-one], B [4a, 1-(2,4,5-trihydroxy-3,6-dimethylphenyl)hexa-2,4-dien-1-one], and C [5, 1-(2,4,5-trihydroxy-3,6-dimethylphenyl)hex-4-en-1-one]. A stable tautomer of oxosorbicillinol (7...

Sampling and storage. The fermentations were conducted in the 100-gallon tanks described by Stefaniak et al. (1946). Samples were removed periodically into 500-ml flasks and ifitered. A 0.5-ml filtered sample was immediately diluted for penicillin assay by addition to previously chilled phosphate buffer in volumetric flasks (4.0 g KH2P04 and 1.0 g K2HPO4 per 500 ml solution in distilled water; ...

This study aims to investigate the biosorption of Pb (II) by living and nonliving biomass Penicillium notatum. notatum PTCC 5074 was purchased from Iran Scientific-Industrial Research Organization in lyophilized form after culturing potato dextrose agar propagated Sabouraud broth medium. The highest adsorption (180.74 187.08 mg/g per dry weight biomass, respectively) at concentration 228 mg/L i...

The effects of some antibiotics on activities of phospholipase A2, B and C were investigated in vitro. Tetracyclines, macrolides, chloramphenicol and carbenicillin inhibited the activity of Crotalus adamanteus phospholipase A2 towards phospholipids of egg-yolk emulsions. When the ability to inhibit the activity of Penicillium notatum phospholipase B towards mixed micelles of phosphatidylcholine...

Sorbic hydroxamic acid was prepared from sorbic acid by esterification and treatment with hydroxylamine (mp 133 to 135 C, pK(a) 8.8). Its ultraviolet spectrum in acid solution had a single absorption maximum at 262 mmu; in alkaline solution the maximal absorption shifted to 255 mmu and significant absorption appeared at 280 to 300 mmu. At concentrations of 0.1% (w/v), sorbic hydroxamic acid pre...

New series of benzophenone imines with general formula Ph2-C=NR; R = Benzyl, 4-Fluorobenzyl, Naphthyl, Phenyl, 4-Nitrophenyl were synthesized by condensation of dichlorodiphenylmethane and different aromatic primary amines (1:1) Those imines were characterized by different physiochemical and spectroscopic techniques like melting point, elemental analysis, FT-IR, multinuclear NMR (H, C). After c...

fungal infections of fish are widespread problem which affect wild and farmed species. the aim of the present study was to isolate and identify fungal flora in cultivated and natural caspian sea acipenser persicus. the samples were obtained from skin, fin and gill of the fish and were inoculated into culture media with antibiotics and incubated at 23±1 ?c. 13 species of fungi isolated from the ...