Cross-sectional and longitudinal studies have been carried out to determine the incidence and clinical significance of eosinophilia in patients taking penicillamine for rheumatoid arthritis. In a cross-sectional study of 204 patients eosinophilia was found with equal frequency during treatment with penicillamine, gold, and nonsteroidal anti-inflammatory drugs. A longitudinal study of 89 patient...

An original flow-injection coupling irreversible biamperometric method is developed for the direct determination of penicillamine. The method depends on electrocatalytic oxidation of penicillamine at a gold electrode and the reduction of permanganate at a platinum electrode to form an irreversible biamperometric detection system. Under the applied potential difference of 0 V, in the 0.05mol/L s...

BACKGROUND Wilson's disease, heralded by severe hepatic insufficiency, is a rare disorder for which emergency liver transplantation is considered to be the only effective therapy. AIMS To report the features of Wilson's disease with severe hepatic insufficiency in a series of 17 patients and, during the second period of the study, to assess the efficacy of a policy consisting of early adminis...

A high-performance liquid chromatographic method for the determination of penicillamine in plasma, whole blood, and urine samples is described. The method uses a commercially available electrochemical detector at a potential of +0.1 V versus the Ag/AgCl reference electrode. This method is selective and sensitive for sulfhydryl compounds. The chromatography separates penicillamine from other end...

Dear Editor, Wilson’s disease (WD) is a rare autosomal recessive disorder of copper homeostasis with a prevalence of 30 affected individuals per million population. Treatment is based on oral chelating agents such as D-penicillamine. Despite its effectiveness, Dpenicillamine presents significant adverse effects. Among them is proteinuria and nephrotic syndrome. An 11 yearold boy was admitted wi...

Severe poisoning resulting from single ingestions of rodenticides, herbicides, or insecticides containing arsenic have been frequently recognized. We record three cases of solubilized arsenic trioxide poisoning in Navajo Indian children and one case of sodium arsenate ingestion in an infant. One fatality occurred during dimercaprol therapy prior to initiation of therapy with D-penicillamine. Th...

Wilson’s disease is an autosomal recessive disorder of copper metabolism associated with deposition in various organs including the heart and brain. Hepatic manifestations are commonest but extrahepatic known which include neuropsychiatric features, haemolytic anaemia, arthropathy etc. Knowledge all these result early clinical suspicion diagnosis confirmed by increased urinary levels decreased ...

To cite: Menzies S, Kirby B. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2015-212482 DESCRIPTION A 42-year-old woman presented with a 5-year history of multiple enlarging skin lesions. Her medical history was significant for Wilson’s disease, for which she had taken penicillamine for approximately 20 years. She had multiple small erythaematous keratotic papul...

Iron and copper release participates in the myocardial injury under ischemic conditions and hence protection might be achieved by iron chelators. Data on copper chelation are, however, sparse. The effect of the clinically used copper chelator D-penicillamine in the catecholamine model of acute myocardial injury was tested in cardiomyoblast cell line H9c2 and in Wistar Han rats. D-Penicillamine ...