The guidelines in the management of pemphigus have evolved over years to enhance treatments outcomes and prognosis. Rituximab (RTX) is today first-line therapy for moderate severe pemphigus. Objective assess response RTX compare its efficacy as 1st or 2nd line treatment. We conducted a single-center retro-prospective study dermatology department Ibn Sina university hospital Rabat (2007-2021). 4...

The adhesive proteins in the desmosome type of cell junction consist of two members of the cadherin superfamily, the desmogleins and desmocollins. Both desmogleins and desmocollins occur as at least three different isoforms with various patterns of expression. The molecular mechanisms controlling the differential expression of the desmosomal cadherin isoforms are not yet known. We have begun an...

Karimunjawa archipelago, marine national park, has been considered to be a relatively pristine area that have more than 90 species of corals. This study was conducted to detect any concentrations heavy metal levels in the tissues of eight coral species. Based on life-forms, selected coral species are classified as massive (Porites lutea and Goniastrea retiformis), submassive (Galaxea fascicular...

Autoimmune bullous diseases are relatively uncommon and their treatment—although generally similar—may vary depending on the dermatologist. Within this group of diseases, the most common are pemphigus vulgaris and pemphigus foliaceus, bullous and mucosal pemphigoid, linear immunoglobulin A disease, and dermatitis herpetiformis. In recent years, the therapeutic arsenal has been extended by new d...

BACKGROUND Trichoscopy is becoming increasingly popular in diagnosing hair and scalp diseases. Scalp involvement in pemphigus is common. The scalp may be the first or only site of clinical manifestation of the disease. OBJECTIVE The aim of this study was to analyze whether trichoscopy may be useful in aiding differential diagnosis of scalp lesions in patients with pemphigus vulgaris and pemph...

BACKGROUND There are two main clinical subsets of pemphigus: pemphigus vulgaris and pemphigus foliaceus. Clinical and epidemiological changes related to both types of pemphigus have been observed in the last years. OBJECTIVES To analyze a 21-year historical case series of pemphigus vulgaris and pemphigus foliaceus in the northeast region of the state of Sao Paulo, where pemphigus foliaceus is...

Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Pemphigus is an autoimmune mucocutaneous bullous disease characterized by auto-antibodies against cell surface antigens of epidermal keratinocytes. Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are the major subtypes. Several other variants have been proposed, including pemphigus erythematosus, pemphigus vegetans, pemp...

BACKGROUND Pemphigus foliaceus and pemphigus vulgaris are endemic in the northeastern region of São Paulo State, Brazil. They are treated mainly with systemic corticosteroids, which may provoke osteoporosis; atherosclerosis, higher blood pressure, insulin resistance, glucose intolerance, hyperlipidemia and abdominal obesity. These side effects of corticoids also constitute criteria for the diag...

BACKGROUND Pemphigus is a common autoimmune blistering disorder in India. However, there are no population based surveys from India available to study the prevalence of this disease. AIMS To estimate the incidence of pemphigus in Thrissur district, Kerala, South India. METHODS Questionnaire based survey was conducted among the practicing dermatologists of Trichur district between 1 st Janua...

OBJECTIVES To evaluate the reactivity of indirect immunofluorescence using rat bladder epithelium as a substrate in patients with pemphigus foliaceus and pemphigus vulgaris from the Department of Dermatology, University of São Paulo Medical School, Brazil. METHODS Thirty-two patients (8 male and 24 female) from the Department of Dermatology, University of São Paulo Medical School, were select...