نتایج جستجو برای: pefloxacin

تعداد نتایج: 311  

Journal: :iranian journal of basic medical sciences 0
shahnaz gauhar department of pharmaceutics, faculty of pharmacy, university of karachi, karachi, pakistan syed ayub ali department of pharmaceutics, faculty of pharmacy, university of karachi, karachi, pakistan harris shoaib department of pharmaceutics, faculty of pharmacy, university of karachi, karachi, pakistan syed baqir shyum naqvi department of pharmaceutics, faculty of pharmacy, university of karachi, karachi, pakistan iyad naeem muhammad department of pharmaceutics, faculty of pharmacy, university of karachi, karachi, pakistan

objective(s) developing and validating a simple, efficient, reproducible and economic reversed phase high performance liquid chromatographic (rp-hplc) method for the quantitative determination of pefloxacin in bulk material, tablets and in human plasma. materials and methods a shim-pack clc-ods column and a mobile phase constituting acetonitrile: 0.025 m phosphoric acid solution (13:87 v/v, ph ...

Journal: :The Journal of antimicrobial chemotherapy 2000
V Tullio A M Cuffini A Bonino A I Palarchio J Roana N Mandras V Rossi N A Carlone

The efficacy of an antibiotic in the treatment of bacterial infections depends upon the interaction of bacterium, drug and phagocytes. In this study we have investigated the influence of AF3013, a new fluoroquinolone, on the activities of mouse peritoneal macrophages against Klebsiella pneumoniae, in comparison with the influence of pefloxacin. Bacterial susceptibility to phagocytosis and intra...

Journal: :International journal of basic and clinical pharmacology 2022

Background: Pefloxacin is a newer broad-spectrum bactericidal fluoroquinolone antibiotic, with superior antibacterial activity in vivo against pathogenic ocular gram-negative and anaerobic microorganisms better pharmacokinetic properties.Methods: 100 bacterial conjunctivitis patients were prescribed topical pefloxacin 0.3% ophthalmological drops monotherapy, 2 each eye after every 3 hours for d...

Journal: :JPMA. The Journal of the Pakistan Medical Association 2011
Saba Qaiser Seema Irfan Erum Khan Tanwir Ahsan Afia Zafar

OBJECTIVES To determine the minimum inhibitory concentrations (MICs) of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem for Salmonella Typhi (S. Typhi) and Paratyphi. METHODS One hundred and fifty four isolates of Salmonella Typhi and S. Paratyphi A, B and C growing in blood culture were selected. MICs of ceftriaxone, azithromycin, pefloxacin, cefipime and imipenem were performed...

2008
Zhe An Qing-Cheng Liang

In the title compound, C(17)H(20)FN(3)O(3)·6H(2)O, the pefloxacin (pef) neutral zwitterion is accompanied by six water mol-ecules of hydration. An extensive network of O-H⋯O and N-H⋯O hydrogen bonds help to establish the crystal packing.

Journal: :Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1996
W W Yew

Chest W W Yew, P C Wong, J Lee and C H Chau Ofloxacin and pulmonary tuberculosis. http://www.chestjournal.org/content/105/5/1624a.citation services can be found online on the World Wide Web at: The online version of this article, along with updated information and ) ISSN:0012-3692 http://www.chestjournal.org/site/misc/reprints.xhtml ( without the prior written permission of the copyright holder...

Journal: :Journal of chemotherapy 1995
K Karak P K De

Sixty clinical isolates of M. tuberculosis, 24 susceptible and 36 resistant to conventional primary antituberculous drugs, were tested against four fluoroquinolones (ciprofloxacin, ofloxacin, pefloxacin and norfloxacin). Ofloxacin and ciprofloxacin were found to be the most active, with minimum inhibitory concentration (MIC) of 0.6 mg/l or less to all strains tested. Strains resistant to isonia...

Journal: :Antimicrobial agents and chemotherapy 1992
R H Gelber A Iranmanesh L Murray P Siu M Tsang

Previously, pefloxacin and ofloxacin were found to be active against Mycobacterium leprae in vitro, in experimental animals, and in clinical trials of lepromatous leprosy patients. In this study, we compared certain more recently developed fluoroquinolones (lomefloxacin, PD 124816, WIN 57273, temafloxacin, and sparfloxacin) with pefloxacin and ofloxacin in M. leprae-infected mice at doses of 50...

Journal: :Antimicrobial Agents and Chemotherapy 1991

2010
Alok Kumar Ravi Nihar Ranjan Biswas Thirumurthy Velpandian Raju Sampangi Supriyo Ghose Rajendra Prasad

Purpose: This study evaluated intraocular penetration of fluoroquinolones (FQs) viz, ofloxacin, pefloxacin, lomefloxacin and sparfloxacin in aqueous, vitreous humors, and plasma after oral/intravenous administration in the subjects undergoing vitrectomy. Methods: Ofloxacin, pefloxacin, lomefloxacin and sparfloxacin were included for oral administration. Only ofloxacin and pefloxacin included fo...

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